1. Drugs/chemicals used in aquaculture
Feed additives (Sulfonamides)
Sulfamerazine (fish grade) and Romet-30
Effective for bacterial infections
Toxicity may occur -
Kidney damage (drug crystal formation in renal tubules)
Clinical signs – bloating/dropsy (stomach full of water)
Commercial availability in feed has limited many problems

2. Drugs/chemicals used in aquaculture
Sulfonamides (continued)
Sulfamerazine (fish grade)
No longer available
Romet-30
Suggested dose (furunculosis) – 50mg/kg fish/day for 5 to 7 days
Also effective for ESC

3. Drugs/chemicals used in aquaculture
Terramycin (oxytetracycline) – TM50
Generally drug of choice in aquaculture
Recommended dose – 55-83mg/Kg fish/day for 10 days
Effective against gram neg. bacteria (BKD?)
ERM, Furunculosis, CWD, etc.
Should not be fed on prophylactic basis!
Resistance to oxytetracycline can occur in most bacterial fish pathogens (Meyer and Schnick 1989)

4. Drugs/chemicals used in aquaculture
Therapeutants added to water
Methods
Static bath – most reliable for raceways/tanks/troughs
Constant flow – safe and can be used in most situations when fish reared in running water
Prolonged –
Chemicals
Formalin
Most widely used agent in fish culture
(solution contains 37% formaldehyde in water)

5. Drugs/chemicals used in aquaculture
Chemicals (cont.)
Quaternary Ammonium compounds
Benzalkonium chloride/Hyamine
Now only limited use in food fish
Potassium Permanganate
Strong oxidizing agent

6. Drugs/chemicals used in aquaculture
Chemicals (cont.)
Copper Sulfate
Algaecide/bactericide/parasiticide
Can produce kidney necrosis, destruction of hematopoietic tissue, increased liver fat and inhibition of digestive enzymes.
NaCl (salt)
Most overlooked treatment
Can be very effective
3% recommended if possible (10-30 min)