1. UKPDS Paper 35 Slides © University of Oxford Diabetes Trials Unit
UKPDS 35. Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes: prospective observational study. British Medical Journal 2000; 321:
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2. Any Diabetes Related Endpoint. 5 1 6 7 8 9
21% decrease per 1% decrement in HbA1c
p<0.0001
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

3. Diabetes Related Deaths
21% decrease per 1% decrement in HbA1c
p<0.0001 . 5 1 6 7 8 9
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

4. All Cause Mortality p<0.0001 Hazard ratio
14% decrease per 1% decrement in HbA1c
p<0.0001 . 5 1 6 7 8 9
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

5. Fatal and Non-Fatal Myocardial Infarction
14% decrease per 1% decrement in HbA1c
p<0.0001 . 5 1 6 7 8 9
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

6. Fatal and Non-Fatal Stroke. 5 1 6 7 8 9
12% decrease per 1% decrement in HbA1c
p=0.035
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

7. Microvascular Endpoints. 5 1 6 7 8 9
37% decrease per 1% decrement in HbA1c
p<0.0001
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

8. Cataract Extraction p<0.0001 Hazard ratio. 5 1 6 7 8 9
19% decrease per 1% decrement in HbA1c
p<0.0001
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

9. Amputation or Death from Peripheral Vascular Disease. 1 2 5 6 7 8 9
43% decrease per 1% decrement in HbA1c
p<0.0001
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

10. Heart Failure p=0.016 Hazard ratio. 5 1 6 7 8 9
16% decrease per 1% decrement in HbA1c
p=0.016
Updated mean HbA1c
Hazard ratio
UKPDS 35. BMJ 2000; 321:

11. Myocardial Infarction and Microvascular Disease
Updated mean HbA1c (%)
Incidence per 1000 patient-years
UKPDS 35. BMJ 2000; 321:

12. UKPDS 35 Summary
There is a direct relationship between the risk of complications of diabetes and glycaemia over time
No threshold of glycaemia was observed for a substantive change in risk for any of the clinical outcomes examined
The lower the glycaemia the lower the risk for complications
The rate of increase of risk for microvascular disease with hyperglycaemia is greater than that for macrovascular disease