1. Background: There are many diseases that involve the gastrointestinal tract Treatment depends upon specific diagnosis This involves identifying both the nature of the disease and its precise location within the GI tract

2. Examples of common diseases Ulcers Cancers Inflammation (colitis, ileitis,gastritis) Arteriovenous malformations Infections

3. Problem: How to visualize the gastrointestinal tract in order to diagnose and treat?

4. ANATOMIC DISTRIBUTION Gastrointestinal Tract Stomach Small bowel Rectum Colon Esophagus

10. Endoscopic view of gastric ulcer

13. We were still left with about 20 feet of small bowel that could not be reached by endoscopes from above and below

17. Antenna ASIC transmitter Batteries CMOS imager Lens Illuminating LEDs Schematic diagram of M2A capsule

19. Normal

20. Arteriovenous malformation

22. Arteriovenous malformation with active bleeding

23. NSAID ulceration

24. Ischemic ulceration

25. Carcinoid tumor