1. C-myc Presented by Tavia Clark

2. c-Myc: The Quintessential Oncogene Transcription factor involved in: –Cell growth –Cell proliferation –Repression of gene transcription –Apoptosis –Angiogenesis

10. TABLE 1 Growth inhibition and apoptosis following treatment with antisense oligonucleotides to c-myc Growth inhibitionApoptosis Cell or Tumorin vivoin vitroin vivoin vitroReference Human acute lymphoblastic leukemia (CEM-C7) + +18 Burkitt's lymphoma lines 30 Ramos (EBV−) + + Daudi (EBV+) + − Small cell lung cancer lines GLC4, GLC4-cDDP a, GLC4-Adr + −46 Human erythroblasts + −47 Human CML blasts b ++??48 Melanoma lines c ++++ 49, 50 Thyroid cancer lines + ?51 Orbital fibroblasts + −52 Monomyeloid cells (HL-60) + +36 Burkitt's lymphoma (Daudi, ST486) + ?53 Ovarian cancer lines + +e+e 54 d Lymphoma U937 +55 e Breast Cancer MCF-7 +55 Ewing's sarcoma CHP-100 +55 Burkitt's lymphoma ST-486 +55 Breast cancer (MCF-7, MDA-MB-231) + ?56 Human T lymphocytes +IL-2 or PHA + −57 Burkitt lymphomas (ST486, JD38) + ?58 Hematopoietic cells + ?59 Esophageal cancer cells + +44 *Symbols: +, effect tested for and seen; −, effect tested for and not seen; ?, not tested (or not reported)

12. Links http://arjournals.annualreviews.org/doi/full/10.1146/annurev.physiol.60.1.57 5?cookieSet=1http://arjournals.annualreviews.org/doi/full/10.1146/annurev.physiol.60.1.57 5?cookieSet=1 http://www.myccancergene.org/index.asp http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1550296 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T23- 44Y0Y3F- 1&_user=130907&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct= C000004198&_version=1&_urlVersion=0&_userid=130907&md5=aa23778e e7ca3420a6b4cb277d165126http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T23- 44Y0Y3F- 1&_user=130907&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct= C000004198&_version=1&_urlVersion=0&_userid=130907&md5=aa23778e e7ca3420a6b4cb277d165126 http://www.tumor-gene.org/cgi-bin/TGDB/tgdb_fetch_gene.cgi?gene=myc http://www.cancerindex.org/geneweb/MYC.htm http://news-service.stanford.edu/news/2004/october13/med-felsher- 1013.htmlhttp://news-service.stanford.edu/news/2004/october13/med-felsher- 1013.html

13. Articles Bruno Amati, Konstantinos Alevizopoulos and Jaromir Vlach, “MYC and the Cell Cycle,” Frontiers in Bioscience, 3, d250-268 (1998) Jonas A Nilsson and John L Cleveland, “Myc pathways provoking cell suicide and cancer,” Oncogene, 22, 9007-9021 (2003) J Craig Cohen, et. al. “Transient in utero knockout (TIUKO) of C- MYC affects late lung and intestinal development in the mouse,” BMC Developmental Biology, 4:4 (2004) E. Brad Thompson, “The many roles of c-Myc in apoptosis,” Annual Review of Physiology, 60, 575-600 (1998) Werner Lutz, Javier Leon and Martin Eilers, “Contributions of Myc to tumorigenesis,” BBA Reviews on Cancer, 1602:1, 61-71 (2002) Amy Adams “Switching off cancer gene turns cells healthy in mice,” Sanford Report, October 13, 2004 Bruna Pucci, Margaret Kasten, and Antonio Giordano, “Cell cycle and apoptosis,” Neoplasia 2:4, 291-299 (2000)