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КОМПЬЮТЕРНЫЙ АНАЛИЗ КОНСЕРВАТИВНОСТИ АЛЬТЕРНАТИВНОГО СПЛАЙСИНГА В ОРТОЛОГИЧНЫХ ГЕНАХ Государственный научно-исследовательский институт генетики и селекции.

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Presentation on theme: "КОМПЬЮТЕРНЫЙ АНАЛИЗ КОНСЕРВАТИВНОСТИ АЛЬТЕРНАТИВНОГО СПЛАЙСИНГА В ОРТОЛОГИЧНЫХ ГЕНАХ Государственный научно-исследовательский институт генетики и селекции."— Presentation transcript:

1 КОМПЬЮТЕРНЫЙ АНАЛИЗ КОНСЕРВАТИВНОСТИ АЛЬТЕРНАТИВНОГО СПЛАЙСИНГА В ОРТОЛОГИЧНЫХ ГЕНАХ Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ГосНИИгенетика)

2 GENE organism 1 organism 2

3 GENE organism 1 organism 2

4 GENE exon 1exon 2 … exon 4 exon 3exon m-1exon m События в ортологичном гене : 1.консервация экзона 2.интронная вставка в экзон 3.делеция интрона 4.делеция экзона

5 isoform 1 isoform 2 GENE Классификация альтернатив 1. удержанный интрон

6 isoform 1 isoform 2 GENE 2. альтернативный донорный сайт Классификация альтернатив 1. удержанный интрон

7 isoform 1 isoform 2 GENE 2. альтернативный донорный сайт Классификация альтернатив 1. удержанный интрон 3. альтернативный акцепторный сайт

8 GENE isoform 1 isoform 2 2. альтернативный донорный сайт Классификация альтернатив 1. удержанный интрон 3. альтернативный акцепторный сайт 4. кассетный экзон

9 GENE isoform 1 isoform 2 2. альтернативный донорный сайт Классификация альтернатив 1. удержанный интрон 3. альтернативный акцепторный сайт 4. кассетный экзон 5. чередующийся экзон 1. внутренний Классификация экзонов и кодирующих сегментов 3. внешний isoform 1 isoform 2

10 coding segment 1 coding segment 2 … coding segment n-1 coding segment 3 coding segment n coding segment 4 isoform 1 isoform 2 isoform 3 isoform 4 GENE exon 1exon 2 … exon 4exon 3exon m-1exon m isoform 1isoform 2 … isoform k-1 isoform k coding segment 1 coding segment 2 coding segment 3 coding segment 4 coding segment 5 coding segment 6

11 Dme, Dps Aga

12 Dme, Dps Aga

13 Dps Aga Dme

14 Dme, Dps Aga stop (combined with acceptor site)

15 Dme, Dps Agaiiiiiiiv

16 Evolution of the exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes D.B.Malko, V.J.Makeev, A.A.Mironov, M.S.Gelfand Genome Research, 2006 Apr;16(4):505-509. Epub 2006 Mar 6.

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