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Cytoskeleton IV Chapter 16
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Mechanochemical cycle of myosin
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DVD clip 74
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Striated vs. smooth muscle cells
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Thick and thin filaments in smooth muscle cells
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Skeletal muscle cells form by the fusion of many muscle cell precursors called myoblasts 50 micrometers wide, several cm long
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Skeletal muscle cells in rats showing blue stained nuclei
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Skeletal Muscle Myofibrils
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Closeup of two sarcomeres
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Schematic diagram showing components of dark and light bands
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Insect flight muscle viewed in cross section show myosin and actin packed together
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Sliding filament model of muscle contraction
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Accessory proteins in a sarcomere
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Ion Channels at Neuromuscular Junction
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Ca2+ release channel is opened by transmembrane protein in tubule
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Two membrane system that relays signal to contract muscle cells
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Electron micrograph showing 2 T tubules
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Muscle contraction is controlled by troponin troponin can pull tropomyosin of myosin binding sites
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Ca 2+ relieves tropomyosin blockage
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Cell Cycle and Programmed Cell Death Chapter 17
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The cell cycle can be studied in a cell free system
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The cell cycle is often studied in immortalized mammalian cell lines
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Activation of a cyclin dependent kinase
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CdK activity can be suppressed by inhibitory phosphorylation
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CdK activity can be suppressed by inhibitory proteins
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Cell fusion experiments
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Assembly of pre-replicative complex during G1 phase
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Entry into mitosis is blocked by incomplete DNA replication Hydroxyurea blocks DNA synthesis Caffeine causes failure of checkpoint
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The Rb protein acts as a brake in mammalian cells
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Overview of cell cycle control system
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