1. The human genome Lander et al. 2001 Venter et al. 2001 Patil et al. 2001 Gabriel et al. 2002 Reich et al. 2001 Sabeti et al. 2002 Yu et al. 2002

15. Repeats Genome size: –Yeast: 12 Mbp –Human: 3.000 Mbp –Amoeba: 600.000 Mbp Human: –Coding Sequence: < 5% –Repeats: >50 %

22. The Arabidopsis Genome Initiative (2000)

23. 10% of genome is duplicated 100.000 SNPs are derived from paralogous sequences

24. tRNA anticodons Frequency of codon in protein sequences Count of tRNA anticodons

28. The human proteome 74 % have homologs from other species in database Contains 61 % of Drosophila proteome Contains 43 % of C.elegans proteome Contains 41 % of S. cerevisae proteome

30. Human-Mouse 1000 7TM receptors –Human: 60% pseudogenes –Mouse: 10% pseudogenes