1. CT COLONOSCOPY

2. Turki Alhazmi,MB.CHB, FRCPC, dABR Interventional Radiology-Body MRI Ass. Prof. Faculty of Medicine Umm Al Qura University Makkah-Saudi Arabia

3. Colorectal Cancers 3rd most common cancer in men and women The age range is late 40s to 70s in average-risk patients 20% occur in high risk genetically predisposed patients 80% occur sporadically in otherwise low risk individuals

4. “The adenoma carcinoma sequence”

6. risk factors for transformation into colorectal cancer through the “adenoma- carcinomasequence Polyps greater than 10 mm in diameter >3 in number, regardless of their size

7. “The adenoma carcinoma sequence” Interruption of this progression by: detection and removal of threatening pre- cursor adenomas by endoscopic polypectomy results in a decrease of cancer related mortality by 30%

8. Colorectal Cancers Arise from pre-existing adenomatous polyp Requiring10–15 years The majority of adenomas that will develop into cancer are polypoid or villous in shape

9. Colorectal Cancers The risk of an adenoma (5 mm or less )to develop into cancer is significantly low, approximating 0.9%

10. Screening Asymptomatic At age of 50 years Fecal occult blood + Colonoscopy or CTC Every five years, the combination of fecal occult blood and colonoscopy or CTC Every five years, double contrast barium enema

11. Screening Conventional colonoscopy is still the gold standard for colon cancer screening Cancers have also been missed by conventional colonoscopy

12. Screening Why cancers are missed on conventional colonoscopy: 1.poor bowel prep 2.Slippage of the endoscope around flexures 3. redundant colon 4.misinterpretation of findings 5.failure to biopsy

13. Conventional Colonoscopy Adverse Outcome Hemorrhage & Perforation : most common Perforation rate 0.2 - 0.4% after diagnostic colonoscopy 5% increases in perforation with polypectomy

14. SENSETIVITY CTCCC 10 mm polyp93.9 %87.5 % 8 mm polyp93.8 %92.3 % 6 mm polyp88.7 %91.5 %

15. SPECIFICITY CTCCC 10 mm polyp96 %96.1 % 8 mm polyp92.2 %91.6 % 6 mm polyp79.6 %77.1 %

16. Screening The sensitivity and specificity per patient and per polyp were similar There is no statistically difference between CT COLONOSCOPY (CTC) and Conventional Colonoscopy for adenomas detection greater than 10 mm

17. CTC VS DCBE sensitivity and specificity of polyp detection is higher for CTC compared to DCBE

18. Indications The indications for CTC closely follow the indications for conventional optical colonoscopy with few exceptions

20. CTC VS CC If you have a patient who is Elderly With cardiovascular disease With bleeding diathesis With history of failed colonoscopies CTC > CC> DCBE

21. CTC VS CC CTC is relatively fast without the need for sedation Less post procedure discomfort CTC than CC

23. Colonoscopia Virtual-2.mp4

26. Virtual disection

31. Proper cleansing of the colon is essential Bowel cleansing for CTC is similar to barium enema and standard colonoscopy