1. Immunology Overview

2. Innate vs Acquired Immunity Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms –Fever –Inflammation –Complement –Toll and Nod Antigen specific and initially slow Memory Lymphocytes Humoral and Cellular Exquisitely Specific Recognition molecules

3. Eukaryote Innate Immunity

4. Cells of the Immune System

5. The Immune System

6. The Clonal Selection Theory

7. Primary vs Secondary Response

8. Antigenicity Antigen - any molecule that binds to and activates the specific receptors of lymphocytes –Immunogenicity –Specificity Epitopes Some molecules (haptens) have specificity but no immunogenicity -- these need a carrier –Digoxigenin –peptides

9. DIG - KLH

10. Requirements for Immunogenicity Foreignness High Molecular Weight Chemical Complexity Degradability Host Factors –Genetics –Route of encounter / Adjuvants

11. Protein Structure

12. Myoglobin Epitopes

13. Lysozyme Epitopes

14. Compare Epitope Structures

15. Antibody Structure

16. The 5 Antibody Classes

17. Mammalian Antibody Isotypes

18. The Immunoglobulin Superfamily

19. The Central Dogma

20. and GOD said, “Let there be light chains!”

21. Light chain exon rearrangement

22. “and let there be heavy chains!”

23. The Clonal Selection Theory

24. Monoclonal Antibodies