1. Principles of Immunology Transplantation Immunology 4/25/06

2. Word/Terms List
Allograft
Autograft
GVH
HLA
Isograft
MHC
Xenograft

3. Transplantation Immunology
Types of transplants
Autograft
Isograft
Allograft
Xenograft

4. Graft Rejection First set Second set
Analogous to primary and secondary antibody response

7. Causes of Rejection MHC – HLA antigens in humans Haplotypes
DTH reaction
Cell-mediated immunity

8. Stages of Rejection Sensitization- APCs from donor APCs from host
“Passenger leukocytes”
CD8 and CD4 both react

9. Stages of Rejection Effector stage C mediated Ab response ADCC CTLs
DTH

11. Compatibility Tests ABO Microcytotoxicity Mixed lymphocyte reaction
Pre existing Ab
C mediated
Mixed lymphocyte reaction
Measures T helper activation
Uses radioactive thymidine as determinant

15. Clinical Types of Rejection
Hyperacute
<24 hours
Preexisting Ab
ABO mismatch
Acute
Weeks
Macrophages
Cytokines
Chronic
Months or longer
Humoral and cell-mediated

17. General Immunosupression
Mitotic Inhibitors
Affects all rapidly dividing cells
Steroids
Anti inflammatory
Cytokine inhibitors
Inhibits T cell proliferation

18. Specific Immunosupression
Monoclonal Ab
Anti CD3
Blocking co stimulation
CTLA injection

19. Immune Tolerance Non immunogenic tissue Privileged sites
Induced tolerance