1. BIOST 536 Lecture 14 1 Lecture 14 – Stratified Models Outline  Description of stratified models  Exact and approximate conditional likelihood  Comparison to standard logistic regression models  Comparison to Mantel-Haenszel

2. BIOST 536 Lecture 14 2 Leisure world data Suppose they stratified on 5-year age groups post hoc, rather than forming matched sets Multiple cases and controls in each stratum Need a minimum of one case and one control per stratum Cases are compared to only controls within their stratum and the results accumulated over all strata

3. BIOST 536 Lecture 14 3 Underlying likelihood

4. BIOST 536 Lecture 14 4 Likelihood

5. BIOST 536 Lecture 14 5 Example Leisure World

6. BIOST 536 Lecture 14 6 Example Leisure World

7. BIOST 536 Lecture 14 7 Alcohol/tobacco example

8. BIOST 536 Lecture 14 8 Alcohol/tobacco example

9. BIOST 536 Lecture 14 9 Alcohol/tobacco example

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12. BIOST 536 Lecture 14 12 Alcohol/tobacco example

13. BIOST 536 Lecture 14 13 Alcohol/tobacco example

14. BIOST 536 Lecture 14 14 Alcohol/tobacco example

15. BIOST 536 Lecture 14 15 Binary exposure variable

16. BIOST 536 Lecture 14 16 Binary exposure variable

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18. BIOST 536 Lecture 14 18 Binary exposure variable

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23. BIOST 536 Lecture 14 23 Example

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