1. Discovery Park: A Paradigm for Interdisciplinary Research A. H. Rebar, DVM, Ph.D. Executive Director of Discovery Park and Senior Associate Vice President for Research

2. Discovery Park Integrated Centers An ideal center will excel in five dimensions… Quality Economic development Interdisciplinary Leverage Leadership Burton D. Morgan Center for Entrepreneurship Birck Nanotechnology Center Gerald D. and Edna E. Mann Hall Bindley Bioscience Center Discovery Learning Center – to open 2009

3. Assoc. VPR & Dir. University Research Administration Interim Provost William R. Woodson Vice President for Research Richard O. Buckius Sr. Assoc. VPR & Exec. Dir. of Discovery Park Alan H. Rebar Assoc. VPR Research Development & Research Support Infrastructure OVPR/DP Business and Sponsored Programs Office Dir. Sponsored Program Services President France A. Córdova

4. Founded 19612001 Purpose Start-up companiesInterdisciplinary research Location Off-Campus US 52 Highway Main Campus State Street People 2878 employees~1000 faculty members # Buildings 38 4 completed; 1 broke ground Sept. 2006 # Companies/Centers 146 Companies11 Centers Area 591 acres40 acres 2/15/08

5. Lilly Endowment support Institutional support Broad mission Synergism among centers Bindley Bioscience Center Birck Nanotechnology Center Burton D. Morgan Center for Entrepreneurship Center for Advanced Manufacturing Center for the Environment Cyber Center Discovery Learning Center e-Enterprise Center Energy Center Oncological Sciences Center Regenstrief Center for Healthcare Engineering Core Centers

6. Discovery Park Infrastructure Administrative –Business team – SPS & Business Admin. –Project coordination –Web site integration –Special events Technical –Research Cores – partnership with academic units –Equipment and facilities

7. Project Based Centers NSF Network for Computation Nanotechnology (NCN) Purdue Homeland Security Institute (PHSI) Purdue Climate Change Research Center (PCCRC) Purdue University Regional Visualization and Analytics Center (PURVAC) NEXTRANS (U.S. Dept. of Transportation Region 5 Transportation Center) Center for Catalytic Design (CCD) Product Life Cycle Management Center of Excellence Center for Prediction of Reliability, Integrity and Survivability of Microsystems (PRISM) Center for Authentic Science Practice in Education (CASPiE) Center for Gene-Environment Interactions Indiana Clinical and Translational Science Institute (CTSI)  Interdisciplinary in nature  Affiliated with a core center  Sponsored programs  Often opportunistic

8. New Initiatives Center for Analytical Instrumentation Development (CAID) Cytometry for Life (C4L) Center for Assistive Technologies DHS University Center of Excellence in Command, Control and Interoperability Purdue Institute of Defense Innovation Energy Frontier Research Centers

9. To Practice or Commercialization Educational or Training Concepts Purdue Research Park Cooperative Education Campus wide Startup Company Licensing Joint Venture Discovery Park is designed to rapidly integrate Purdue with outside partners. An Engine for Indiana’s Economy Value Proposition Project Ideas Seeding Nurturing Executing Discovery Park & University Infrastructure Industry

10. Alfred E. Mann Institute (AMI) at Purdue Alfred E. Mann is a successful entrepreneur in the medical device field. Created $1B+ non-profit Alfred E. Mann Foundation for Biomedical Engineering (AEMFBE) Mission is to expedite development of biomedical technologies at partner universities Endowing $100M+ non-profit Alfred E. Mann Institutes at partner universities (USC, Technion) Purdue is third partner site.

11. AMI Organizational Model Operates under umbrella agreement with Purdue Research Foundation (PRF) to expand our technology commercialization capacity Non-profit institute located in Purdue’s Discovery Park (DP) Governed by Board comprised of half Purdue and half AEMFBE selected members Uses ~$5M endowment income for all operational costs (e.g., rent, staff, resources)

12. AMI Organizational Model (cont.) Invests in and rapidly develops Purdue biomedical technologies Licenses developed technologies to companies (startup through established) Preference given to Indiana companies in order to fuel the local and regional economy Income is shared among inventors, PRF, AMI, AEMFBE

13. AMI Chief Advantages AMI will complete analysis on: –freedom to operate –barriers to market entry –time and cost to market –competitive technologies and market landscape –reimbursement strategies –regulatory approval processes –potential commercial partners Immediate resources will be brought to bear on projects developed by AMI

14. AMI Chief Advantages (cont.) Thus, technology will be subsequently licensed to a company when: – technical risk is significantly reduced: Working prototype(s) Commercial scale demonstration Preclinical and/or clinical studies completed FDA approvals in process or granted – market application is well-defined Result is a higher market value of the technology

15. Accomplishment: Sponsored Awards* ($M) Purdue system wide Discovery Park *Support in collaboration with Development is included. In addition, activity for awards to participating colleges/schools is included. Lilly End. 26 Lilly End. 25 # awards: 62156111188 3774 33324076 3294 3256 2243131 thru’ May 2008 3081210

16. Equipment $17,858,825 Office/Support Space Approx. 59,000 sq. ft. Laboratory Space Approx. 102,000 sq. ft. DP Accomplishment: Value Added Since August 2001

17. Start-Up Contributions$5,644,000 Cost Shares1,061,404 Equipment Grants964,430 Seeds Grants3,709,661 Miscellaneous (e.g., summer grad support)497,865 TOTAL $11,877,360 *As of 2/2007. The total does not include costs of symposia, workshops, director salaries, administrative & business support for grant submissions, business plan competitions, Innovation Realization Laboratory/Technology Commercialization Laboratory, New Ventures Laboratory, CERIAS, EPICS Entrepreneurship Initiative, four endowed Directorships, DP Lectures Series, and other miscellaneous activities such as support of DP Research Cores in both personnel and equipment. Funds from DP to Academic Units*

18. Seeding and Nurturing Start-up Companies 1.Endocyte 2.Griffin Analytical Technologies 3.2K Corporation 4.Biovitesse Inc. 5.Tienta Sciences 6.Indigo BioSystems 7.Prosolia 8.PriProTex* 9.Quadraspec, Inc. 10.Data Tracking Solutions 11.Theme Work Analytics** 12.Brogan Phamaceuticals 13.Advanced Radiotherapeutic Solutions* 14. VEM Smart Systems, LLC 15. M4 Corporation 16. MagSense Life Sciences 17. MatrixBio, LLC 18. Prima Specialty Vectors 19. Stormfront Productions** 20. Identity Alliance** 21. Cytometry for Life** 22. AlGalCo** 23. Kylin Therapeutics, Inc. 24. National Institute of Pharmaceutical Technology Details of licensing are being worked out ** Non Purdue Technology Plus six start-ups by Interns for Indiana program students

19. 5 new interdisciplinary research buildings 3000 students in entrepreneurial activity 500 faculty involved in interdisciplinary research 1000 faculty involved in interdisciplinary research $25 million/year in sponsored research funding $44 million/year in sponsored research funding 8 new start-up companies 20 new start-up companies facilitated in cooperation w/Purdue Research Fdn. 20 corporate partners In 2006, Discovery Park had: Strategic Plan October 2003

20. (GE 3 NIE): Generating Entrepreneurs, Entrepreneurial Ecosystems, and Networks for Indiana’s Economy: A Discovery Park Super Project …in partnership with –the Purdue Research Foundation –the Purdue Office of Engagement –and other organizations/institutions …will develop and implement a series of programs –to enhance IP commercialization –to promote a culture of entrepreneurship throughout the state The outcome will be an Indiana Entrepreneurial Ecosystem.

21. National and International Partnerships Signing of Memorandum of Understanding between Purdue University and the Department of Science and Technology, Government of India Australia China India Israel Puerto Rico Korea Energy crisis Global warming Healthcare delivery Homeland security Learning

22. WOW by 2012  Building facilities for an additional five core centers  $100 million in annual sponsored funding  Thirty additional start-ups assisted and facilitated  Fifty new patent applications based on Discovery Park research  Ten new nationally recognized project centers and institutes  Twenty new partnerships with global institutions

23. Video Clips DP Overview Biotechnology and Nanotechnology Healthcare

24. It IS happening here!! For information on Discovery Park: http://www.purdue.edu/discoverypark Dr. A. H. Rebar, (765) 496-6625; rebar@purdue.edu