1. B-Cell Epitopes
Chapter 10

2. Antibodies

3. Antibody - Antigen interaction
Paratope
Fab
Epitope
Antibody

4. Antibody Effect
Virus or Toxin
Neutralizing Antibodies

5. B-Cells Stem Cell Precurser B-lymphocytes Gene rearrangements
B-lymphocytes each displaying a unique B-cell receptor

6. Gene Shuffling
José Saldanha © Birkbeck College, London WC1E 7HX.

7. B-Cell Activation No Affinity No Affinity Low Affinity
Somatic Hypermutations
High Affinity
Plasma cells
Memory B-cells

8. B-Cell Activation
T Helper Cell
TCR
B Cell
Class II MHC
Bound Peptide

9. Cartoon by Eric Reits

10. Structural Epitopes

11. Discontinuous Epitopes

13. CDR Regions CDR = complementarity determining region
Variable regions
Alpha-carbon trace of the structure of the heavy chain and light chain variable regions of a typical antibody. The framework regions of both chains are shown in grey whilst the complementarity determining regions (CDRs) are coloured individually, i.e.
Heavy chain
CDR 1 = Light blue
CDR 2 = Cerise
CDR 3 = Yellow
Light Chain
CDR 1 = Red
CDR 2 = Green
CDR 3 = Blue
CDR = complementarity determining region