1. Allergy and Hypersensitivity K. J. Goodrum 2006

2. Types of Immune Hypersensitivity Reactions

4. Properties of Inhaled Allergens

5. Penetration of epithelial Barriers by Allergens

6. Early IL-4 response promotes Th2 development that drives B cell class switching to IgE

7. Signaling through Stat6 is necessary for Th2 responses. Th2 cells support IgE responses.

8. Antigen binding to IgE on mast cells leads to amplification of IgE production

9. Mast cell activation affects many tissues

10. Molecules released upon activation of mast cells

12. Toxic granule proteins and inflammatory substances released upon activation of eosinophils

14. Acute vs. late phase inflammatory responses

15. TH2 mediated chronic inflammation in Asthma

16. Treatment approaches for IgE-mediated Allergy

17. Type II Cytotoxic reaction

18. Immune Complex mediated local inflammation such as in Arthus Reaction

19. Serum Sickness: an Immune complex disease

21. Type IV Hypersensitivity Reactions

22. Stages of a Type IV Hypersensitivity Reaction

23. Th1 derived cytokines and chemokines direct Type IV reactions

24. Allergic Contact Dermatitis: A type IV reaction

25. Blistering skin lesions on hand of patient with poison ivy contact dermatitis (a type IV reaction)

26. Granulomatous inflammation is a consequence of chronic Type IV reactions