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Alcohol groups in cyclodextrin substituted with various ethers and/or silyl ethers (-OSiR 3 ) cyclodextrin = D-glucose oligosaccharide Silylated and Alkylated.

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Presentation on theme: "Alcohol groups in cyclodextrin substituted with various ethers and/or silyl ethers (-OSiR 3 ) cyclodextrin = D-glucose oligosaccharide Silylated and Alkylated."— Presentation transcript:

1 Alcohol groups in cyclodextrin substituted with various ethers and/or silyl ethers (-OSiR 3 ) cyclodextrin = D-glucose oligosaccharide Silylated and Alkylated Cyclodextrins Are Used in Chiral GC Columns

2 Various Chiral HPLC Columns Available Various amylose or cellulose derivatives commercially available (D-glucose polysaccharide)

3 Racemic praziquantel Antihelmintic for veterinary use and schistosomiasis in humans Column: Chiralcel OD Detection: 254 nm (UV) Eluent: Hex/IPA/TEA 60:40:0.1 Flow rate: 0.7 mL/min Retention times: 12.4, 14.9 min http://www.thesynapticleap.org/node/276 Chiral HPLC Trace of Racemic Praziquantel


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