1. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology B.E Pruitt & Jane J. Stein AN INTRODUCTION EIGHTH EDITION TORTORA FUNKE CASE Chapter 23, part C Microbial Diseases of the Cardiovascular and Lymphatic Systems

2. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Nasopharyngeal carcinoma Epstein-Barr virus (Human herpesvirus 4) Cancer in immunosuppressed individuals, and malaria and AIDS patients Burkitt’s Lymphoma

3. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Epstein-Barr virus (Human herpesvirus 4) Childhood infections are asymptomatic Transmitted via saliva Characterized by proliferation of monocytes Infectious Mononucleosis

4. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Infectious Mononucleosis Figure 23.20

5. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Cytomegalovirus (Human herpesvirus 5) Infected cells swell (cyto-, mega-) Latent in white blood cells May be asymptomatic or mild Transmitted across the placenta, may cause mental retardation Transmitted sexually, by blood, or by transplanted tissue Cytomegalic Inclusion Disease

6. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Viral Hemorrhagic Fevers Classic Yellow feverFlavivirusAedes aegyptiMonkeys Dengue & DHFFlavivirus A. aegypti A. albopictus No known reservoir Emerging MarbugFilovirus Monkeys (?) EbolaFilovirus Monkeys (?) Lassa feverArenavirus Rodents Argentine hemorrhagic fever Arenavirus Rodents Bolivian hemorrhagic fever Arenavirus Rodents Hantavirus pulmonary syndrome Hantavirus Rodents

7. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Ebola Virus Figure 23.21

8. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Trypanosoma cruzi Reservoir Rodents, opossums, armadillos Vector Reduviid bug American Trypanosomiasis (Chagas’Disease) Figure 23.22, 12.33d

9. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Toxoplasma gondii Toxoplasmosis Figure 23.23

10. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Plasmodium vivax, P. ovale, P malariae, P. falciparum Anopheles mosquito Malaria 12.31b

11. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Malaria Figure 23.25

12. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Malaria Figure 23.24

13. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Malaria Figure 12.19

14. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Leishmaniasis DiseaseVisceral leishmaniasis Cutaneous leishmaniasis Mucocutaneous leishmaniasis Babesiosis Fatal if untreated Papule that ulcerates and scars DisfiguringReplicates in RBCs Causative agent Leishmania donovani L. TropicaL. BraziliensisBabesia microti VectorSandflies Ixodes ticks ReservoirSmall mammals Rodents TreatmentAmphotericin B or miltefosine Atovaquone + azithromycin Geographic distribution Asia, Africa, Southeast Asia Asia, Africa, Mediterranean, Central America, South America Rain forests of Yucatan, South America U.S.

15. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Babesiosis Figure 12.32

16. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Schistosomiasis Figure 23.28

17. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Tissue damage (granulomas) in response to eggs lodging in tissues Schistosomiasis S. haemotobiumGranulomas in urinary bladder wall Africa, Middle East S. japonicumGranulomas in intestinal wallEast Asia S. mansoniGranulomas in intestinal wallAfrican, Middle East, South American, Caribbean Swimmer’s itchCutaneous allergic reaction to cercariae U.S. parasite of wildfowl

18. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Schitstosomasis Figure 23.27a (a) Male and female schitosomes.

19. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Schitstosomasis Figure 23.27b