1. The following slides present some answers….. Please don’t peek before doing the exercise!

2. Flavodoxin family - TOPS diagrams (Flores et al., 1994) 12345 1 234 5

3. Flavodoxin fold: aligning 13 Flavodoxins + cheY 5(  ) fold

4. Protein structure evolution Insertion/deletion of secondary structural elements can ‘easily’ be done at loop sites Can you see this happening at the earlier TOPS slide?

5. Protein structure evolution Insertion/deletion of structural domains can ‘easily’ be done at loop sites N C This is for later……