1. Life course model of cognitive reserve Advanced Psychometrics Methods Web Conference – 2/16/10

2. Workgroup Members Angela Jefferson (AJ) angelaj@bu.eduangelaj@bu.edu Laura Gibbons (LEG) gibbonsl@u.washington.edugibbonsl@u.washington.edu Dorene Rentz (DR) drentz@partners.orgdrentz@partners.org Janessa Carvalho (JC) jocarval@psych.umass.edujocarval@psych.umass.edu Jennifer Manly (JM) jjm71@columbia.edujjm71@columbia.edu Yaakov Stern (YS) ys11@columbia.eduys11@columbia.edu David Bennett (DB) dbennett@rush.edudbennett@rush.edu Rich Jones (RNJ) jones@hrca.harvard.edujones@hrca.harvard.edu

3. MAP Life Course Factors Cognitive Activities Scale (CAS) Early-life activities (ZCAE) Mid-life activities (ZCA40) Late-life activities (ZCA99) Socioeconomic Status (SES) Early childhood SES (ZSESEARLY) Adult SES (ZSESNOED) Education Level (ZEDUC) Late life reading ability - NART (ZSCREAD)

4. MAP Cognitive Protocol FactorNeuropsychological Test Global Cognition Summary Measure of All Tests Episodic Memory WMS-R Logical Memory – Story A East Boston Story Word List Learning Visospatial Ability Judgment of Line Orientation – 15 item Raven’s Progressive Matrices – 16 item Semantic Memory Boston Naming Test – 15 item Verbal Fluency Working Memory WMS-R Digit Span Digit Ordering Perceptual Speed Symbol Digit Modalities Test Number Comparison Stroop Color-Word Interference

5. Basic model for all cognitive outcomes

6. Results – total MAP sample Perceptual speed Episodic memory Working memory Visuospatial Memory Semantic Memory* Global* ZCA99.291.150.056.120.244.211 ZCA40.140.072.027.058.117.100 ZCAE.142.068.039.061.123.103 ZSESNOED.137.027.129.080.146.108 ZSESEARLY.188.132.165.185.189.201 ZEDUC.232.219.280.322.249.308 ZSCREAD.248.204.343.163.189.284 Model R 2.260.127.211.175.217.309

7. Results –MAP sample excluding “possible” dementia Perceptual speed Episodic memory Working memory Visuospatial Memory Semantic Memory* Global* ZCA99.269.055.050.150.191.186 ZCA40.131.027.024.073.092.090 ZCAE.135.031.040.072.100.097 ZSESNOED.139.057.149.052.132.128 ZSESEARLY.202.170.165.181.203.252 ZEDUC.247.327.265.308.293.408 ZSCREAD.228.216.315.114.166.296 Model R 2.249.167.192.162.207.353

8. Results –MAP sample including ONLY “possible” dementia Perceptual speed Episodic memory Working memory Visuospatial Memory Semantic Memory* Global* ZCA99.339.205.017.037.295.262 ZCA40.158.096.008.017.137.121 ZCAE.152.078.011.025.137.115 ZSESNOED.124-.083.048.111.159.073 ZSESEARLY.128.062.155.200.137.171 ZEDUC.167.113.303.373.183.283 ZSCREAD.222.106.331.118.180.271 Model R 2.233.078.186.175.203.264

9. Life Course Factors – Preliminary Conclusions Global Cognition & Visuospatial Abilities Education exerts greatest influence Episodic Memory & Semantic Memory Education exerts greatest influence (except for in MCI/early cognitive decline, in which late life cognitive activities have greatest influence) Working Memory NART exerts greatest influence Perceptual Speed Late life cognitive activities has greatest influence

10. Life Course Factors – Project Status Statistical Analyses “work in progress” Manuscript Development Target completion late March 2010 Recent Abstract Submission ICAD 2010 (Hawaii) – submitted 2/01/10 Possible Future Manuscript Development Examine life course factors in relation to neuropathological markers