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1 Yoder, Wang, & Morris (2004) J Nuc Med, 45(5) 903-911. BP is Sensitive to DA Kinetics For illustration, Consider DA spikes of Constant Area DA Conc. (nM) BP varies with timing of the DA response. (the impulse response is time-varying) DA Conc (nM) BP
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2 Did we discover this? Endres CJ, Carson RE. (1998) Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands. J Cereb Blood Flow Metab 18:1196-1210 they said… (1) DAraclopride
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3 The free tracer is the “shutter” of the “dopamine- camera” Free 11 C-raclopride F RAC (t) The picture ( BP) is “weighted” by the scenes when the shutter is open widest. DA time Free dopamine, DA(t)
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