1. 1 Yoder, Wang, & Morris (2004) J Nuc Med, 45(5) 903-911.  BP is Sensitive to DA Kinetics For illustration, Consider DA spikes of Constant Area DA Conc. (nM)  BP varies with timing of the DA response. (the impulse response is time-varying) DA Conc (nM)  BP

2. 2 Did we discover this? Endres CJ, Carson RE. (1998) Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands. J Cereb Blood Flow Metab 18:1196-1210 they said… (1) DAraclopride

3. 3 The free tracer is the “shutter” of the “dopamine- camera” Free 11 C-raclopride F RAC (t) The picture (  BP) is “weighted” by the scenes when the shutter is open widest. DA time Free dopamine, DA(t)