1. Degradation of Liquid Embolic Polymer - A Pulsatile Flow Model BME 440 Senior Design Project Dr. Strey Dr. Weiliam Chen (customer) Group 1: Sara Goldgraben, Bill Hauser & Mike Savarese September 30 th 2005

2. Aneurysms Outpouching of a blood vessel Guglielmi Detachable Coil (invasive) New Development  Liquid Embolics Combine recombinant human vascular endothelial growth factor (rh VEGF) with a gelable polymer Possible polymers  Chitosan to N-Carboxyl Ethyl Chitosan A combination of chitosan and VEGF

3. Polymer Model Testing Initial Parameters  2D model, 3D model Water Tight, Transparent, Easy to Maintain  Rigid Vasculature  Simulation of Biological Conditions Blood Pulsatile Flow Pump Future Model Design  Elastic Vasculature  Computer Aided Speckle Interferometry (CASI) Our Initial Ideas  Flow Pump, Vasculature, Enclosure