1. Computational Biology, Part 19 Cell Cycle Modeling Robert F. Murphy Copyright  2005-2007. All rights reserved.

2. Assigned Reading Computational Cell Biology by Fall et al, Chapter 10 through section 10.5 (handed out in class) Computational Cell Biology by Fall et al, Chapter 10 through section 10.5 (handed out in class)

3. Cell Cycle model Rise in cyclin/Cdk triggers transition to S phase Rise in cyclin/Cdk triggers transition to S phase Also causes inhibition of active APC Also causes inhibition of active APC Active APC degrades cyclin Active APC degrades cyclin

4. Cell Cycle model X=cyclin/CDK dimer Y=active Cdh1/APC complex m=cell mass A=Cdh1 activator

5. Cyclin/Cdk vs. APC phase plane (Maple worksheet CompCellBiolFigure10- 3.mw) (Maple worksheet CompCellBiolFigure10- 3.mw)

6. Bifurcation of cyclin/Cdk vs. “p” phase plane (Maple worksheet CompCellBiolFigure10- 4.mw) (Maple worksheet CompCellBiolFigure10- 4.mw)

7. Cell Cycle model X=cyclin/CDK dimer Y=active Cdh1/APC complex m=cell mass A=Cdh1 activator

8. Kinetics of cell cycle changes in cyclin and APC (Maple worksheet CompCellBiolFigure10- 6.mw) (Maple worksheet CompCellBiolFigure10- 6.mw)