1. Bimonthly Meeting on August 22, 2008 Chemical Information on Brain Tissue by Different Methods Amarjeet Bhullar

2. We have compared metabolite ratios, calculated using three different methods: Directly Generated by Functool Metabolites Concentration Generated by Functool Gaussian Function Overlapped on metabolite peak

3. S19.6 Exam ID: 4465 June 23, 2008 Patient Name: AD

4. Mathematical Model: Gaussian Function

5. We can solve this integral by numerically and by explicit expression Explicit Expression Numerically

6. How to compute metabolite concentration Spectrum

7. Concentration of the Choline Cho=Area under the curve between 3.34 and 3.19 PPM

8. Concentration of the Creatine Cre=Area under the curve between 3.16 and 3.00 PPM

9. Concentration of the NAA NAA=Area under the curve between 2.19 and 2.02 PPM

10. Voxel #23Functool-1Functool-2Our Calculation Cho/Cre 0.7820.8480.941 Cho/NAA 0.3920.3890.435 Chemical Information on Voxel # 23

11. Voxel #24Functool-1Functool-2Our Calculation Cho/Cre 0.961 1.00 Cho/NAA 0.4490.4410.458 Chemical Information on Voxel # 24

12. Voxel #25Functool-1Functool-2Our Calculation Cho/Cre 1.131.11 Cho/NAA 0.5340.5310.512 Chemical Information on Voxel # 25

13. Voxel #26Functool-1Functool-2Our Calculation Cho/Cre 1.01 1.02 Cho/NAA 0.5940.5920.555 Chemical Information on Voxel # 26

14. Voxel #27Functool-1Functool-2Our Calculation Cho/Cre 0.621 0.622 Cho/NAA 0.780 0.876 Chemical Information on Voxel # 27

15. Voxel #25Functool-1Functool-2Our Calculation Cho/Cre 1.071.201.11 Cho/NAA 0.6260.6250.567 Chemical Information on Voxel # 30

16. Conclusion : There is no significant difference between our calculation and Functool. Suggestions are welcome