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Bimonthly Meeting on August 22, 2008 Chemical Information on Brain Tissue by Different Methods Amarjeet Bhullar.

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Presentation on theme: "Bimonthly Meeting on August 22, 2008 Chemical Information on Brain Tissue by Different Methods Amarjeet Bhullar."— Presentation transcript:

1 Bimonthly Meeting on August 22, 2008 Chemical Information on Brain Tissue by Different Methods Amarjeet Bhullar

2 We have compared metabolite ratios, calculated using three different methods: Directly Generated by Functool Metabolites Concentration Generated by Functool Gaussian Function Overlapped on metabolite peak

3 S19.6 Exam ID: 4465 June 23, 2008 Patient Name: AD

4 Mathematical Model: Gaussian Function

5 We can solve this integral by numerically and by explicit expression Explicit Expression Numerically

6 How to compute metabolite concentration Spectrum

7 Concentration of the Choline Cho=Area under the curve between 3.34 and 3.19 PPM

8 Concentration of the Creatine Cre=Area under the curve between 3.16 and 3.00 PPM

9 Concentration of the NAA NAA=Area under the curve between 2.19 and 2.02 PPM

10 Voxel #23Functool-1Functool-2Our Calculation Cho/Cre 0.7820.8480.941 Cho/NAA 0.3920.3890.435 Chemical Information on Voxel # 23

11 Voxel #24Functool-1Functool-2Our Calculation Cho/Cre 0.961 1.00 Cho/NAA 0.4490.4410.458 Chemical Information on Voxel # 24

12 Voxel #25Functool-1Functool-2Our Calculation Cho/Cre 1.131.11 Cho/NAA 0.5340.5310.512 Chemical Information on Voxel # 25

13 Voxel #26Functool-1Functool-2Our Calculation Cho/Cre 1.01 1.02 Cho/NAA 0.5940.5920.555 Chemical Information on Voxel # 26

14 Voxel #27Functool-1Functool-2Our Calculation Cho/Cre 0.621 0.622 Cho/NAA 0.780 0.876 Chemical Information on Voxel # 27

15 Voxel #25Functool-1Functool-2Our Calculation Cho/Cre 1.071.201.11 Cho/NAA 0.6260.6250.567 Chemical Information on Voxel # 30

16 Conclusion : There is no significant difference between our calculation and Functool. Suggestions are welcome


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