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Bimonthly Meeting on August 22, 2008 Chemical Information on Brain Tissue by Different Methods Amarjeet Bhullar
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We have compared metabolite ratios, calculated using three different methods: Directly Generated by Functool Metabolites Concentration Generated by Functool Gaussian Function Overlapped on metabolite peak
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S19.6 Exam ID: 4465 June 23, 2008 Patient Name: AD
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Mathematical Model: Gaussian Function
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We can solve this integral by numerically and by explicit expression Explicit Expression Numerically
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How to compute metabolite concentration Spectrum
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Concentration of the Choline Cho=Area under the curve between 3.34 and 3.19 PPM
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Concentration of the Creatine Cre=Area under the curve between 3.16 and 3.00 PPM
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Concentration of the NAA NAA=Area under the curve between 2.19 and 2.02 PPM
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Voxel #23Functool-1Functool-2Our Calculation Cho/Cre 0.7820.8480.941 Cho/NAA 0.3920.3890.435 Chemical Information on Voxel # 23
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Voxel #24Functool-1Functool-2Our Calculation Cho/Cre 0.961 1.00 Cho/NAA 0.4490.4410.458 Chemical Information on Voxel # 24
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Voxel #25Functool-1Functool-2Our Calculation Cho/Cre 1.131.11 Cho/NAA 0.5340.5310.512 Chemical Information on Voxel # 25
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Voxel #26Functool-1Functool-2Our Calculation Cho/Cre 1.01 1.02 Cho/NAA 0.5940.5920.555 Chemical Information on Voxel # 26
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Voxel #27Functool-1Functool-2Our Calculation Cho/Cre 0.621 0.622 Cho/NAA 0.780 0.876 Chemical Information on Voxel # 27
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Voxel #25Functool-1Functool-2Our Calculation Cho/Cre 1.071.201.11 Cho/NAA 0.6260.6250.567 Chemical Information on Voxel # 30
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Conclusion : There is no significant difference between our calculation and Functool. Suggestions are welcome
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