1. Huntington’s Disease II: Genetics and cell pathology Neurobiology of Disease

3. 1983 - Gusella, Wexler and colleagues identify locus 1993 - Huntintin cloned, CAG, poly Q repeats identified

4. Myers 2004 NeuroRx. 1:255-62.

5. Paulson Fischbeck Annu. Rev. Neurosci. 1996 19:79-107

6. Mutant mice:

7. Rubinsztein 2002

8. Harjes, Wanker Trends Biochem. Sci. 28:425

10. Landles,Bates 2004 EMBO Reports 5:958

11. Landles,Bates 2004 EMBO Reports 5:958

12. Neurotrophins and Receptors NGF BDNF NT4/5 NT3 NGF BDNF NT3 NT4/5 TrkA TrkB TrkC p75 NTR (Adapted from Neet & Campenot, 2001)

13. Bacquet et al. 2004 J Neurosci. 24:4250-8

14. Arrasate et al. 2004 Nature 431:805

15. Fig. 2

18. Gauthier et al. 2004 Fig. 1

25. Schroer 2004