1. 1 Portable Heart Attack Detector (PHAD) Characterization Presentation April 6, 2005 Technion – Israel Institute of Technology Department of Electrical Engineering High-Speed Digital Systems LabSupervisor Daniel Alkalay System architectures Nir Gluzman Alexei Iolin

2. 2 Did You Know? More than 1.2 million Americans will suffer a heart attack, where about 502,000 of these people will die! 340,000 of them in an ER or BEFORE they reach a hospital. Surviving a heart attack depends on the treatment that is given within the first hour of the heart attack. Most common reason for treatment delay is patient unawareness. Source:American Heart Association, 2004 estimation.

3. 3 The Solution Portable Heart Attack Detector

4. 4 AGENDA Medical Background Project Objective System Block Diagram NI/FPGA – Pros & Cons Project Time-Table Summary

5. 5 Medical Background ECG = Electrocardiogram Recording of heart’s electrical activity. Measures rate and regularity. Used to diagnose diseases.

6. 6 Basic ECG complex Medical Background (cont.) R P Q S T

7. 7 Heart attack (Myocardial Infarction) An event that results in permanent damage to the heart. myocardium = heart muscle. infarct = die. Medical Background (cont.) Q-waves and inverted T-waves are two diagnostic wave forms seen in old heart attacks and new heart attacks respectively.

8. 8 ST-Elevation (STEMI) Elevation of ST-segment relative to PR or TP segment. ST-elevation is a sign for coming heart attack (acute myocardial infarction). Short PR interval - very difficult for computer algorithms to find the isoelectric reference level.

9. 9 Develop a system that measures and displays RR-rate, ST-elevation and alert to wide-QRS. Implement the system on National-Instrument (*) Real-Time FPGA development environment using LabView graphical language. Project Objective (*) (*) website: http://ni.com PXI-7831R

10. 10 System Block Diagram Biosensors A/D interface Detection of ECG characteristic points with filter-bank Detection of RR-rate, ST-elevation, wide-QRS Abnormalities alert

11. 11 Filter-Bank Block Diagram Input signal is sampled at 360Hz.

12. 12 Abnormalities detection (cont.) RR-rate & wide-QRS detection ST-elevation detection R-detection Decomposed Signal

13. 13 Abnormalities detection (cont.) R-detectionRR-rate & QRS-duration ST-elevation

14. 14 NI/FPGA – Pros & Cons Pros Rapid prototype system. Dedicated hardware and software. Cons NI development environment is non-conventional – design extraction to other non NI/FPGA environments is NOT possible. VHDL code is hidden from user.

15. 15 Project Time-Table Study of NI/FPGA & LabView development environment 3 Implementation 5 Design verification 2 Limited clinical experiments (optional) 1 Final report and project summary 2 Subject Time period (weeks)

16. 16 Summary Patient need for PHAD. Detailed design of the system. Pros & cons of NI development environment.

17. 17 Questions?