1. Penicillin G Prepared by Abdurhman assiri

2. Penicillin G is one of the natural penicillins. Pregnancy Category B

3. CLINICAL APPLICATIONS  The drug is frequently used for streptococcal infections that include pneumonia, otitis media, meningitis, and septic arthritis.

4. PHARMACOKINETICS Peak conc. Of IV after 1hr, and IM Pen. G benzathine after 24 hr. bioavailability =30%. PB= 65%.Poor across BBB. Elimination half life= 20-60 min. 30% metabolized by liver. Execrated mainly by renal

5. Dosing information Oral dose 375 – 1000 mg/day IV doses.3 million – 1.2 million Doses adjustment in renal disorder Pediatic doses 20-50 mg/kg/day

6. Side effect Fever,rash,anemia,renal dysfunction Hypersenesitivity, thrompophelibitis.

7. Drug interaction Aminoglycoside AB,tetracycline.OC,probencide

8. Contra-indicaition In anaphylaxis patients

9. The End