Download presentation
Presentation is loading. Please wait.
1
Tissue’s Response to Mechanical Stimuli By: Christopher Gambino Mentors: Engin Ozcivici,Shiyun Xu, Engin Ozcivici,Shiyun Xu, Russell Garman, Dr. Stefan Judex
2
Introduction Tissue loss is an increasing problem in today’s society. It will effect almost everyone from astronauts in space to sick and injured people that require bed rest. Many methods to prevent this loss have been tried from exercise to medication. During this research it was noticed that some strains of mice lose tissue faster than others.
3
Methods Resistant and susceptible strains of mice were crossbred to create an inbred F2 population. These mice were then scanned at the age of 17 weeks. They then had their hind-limbs immobilized to simulate spaceflight or bed rest. After 3 weeks of this they are scanned again for a second time. The hind-limbs were then re-mobilized and the mice were allowed to use them for an additional 3 weeks before being scanned 3 rd and final time.
4
Results During the 1-3 week period bone volume decreased an average of 1%. During the 3-6 week period bone volume increased an average of 4% During weeks 1-3 the muscle volume decreased and average of 10% During Weeks 4-6 muscle mass volume increased 7%
5
Discussion The bone seemed to be more responsive to mechanical loading (walking) than unloading (immobilized). The reverse of this is true for the muscle. The distribution of loss/gain rather than being grouped around one value suggests that there is a controlling factor that was spread through the genetically heterogeneous population.
6
Future Research Data on different sections of bone is needed and is currently being worked on. Further research into the genetics of the individual mouse is needed to isolate any controlling factor.
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.