1. Bioinformatics and Comparative Genome Analysis Fredj Tekaia Institut Pasteur tekaia@pasteur.fr Introduction Bioinformatic and Comparative Genome Analysis Course HKU-Pasteur Research Centre - Hong Kong, China August 17 - August 29, 2009 Bioinformatic and Comparative Genome Analysis Course HKU-Pasteur Research Centre - Hong Kong, China August 17 - August 29, 2009

2. Bioinformatics and Comparative Genome Analysis August 16 - August 29, 2009 HKU-Pasteur Research Centre - Hong Kong Course web page: http://www.pasteur.fr/~tekaia/BCGA2009.html Organizers/Contact: Roberto Bruzzone, HKU-Pasteur Research Centre - Hong Kong; Si Lok, Genome Research Centre the University of Hong Kong; Tin Wee Tan, National University of Singapore - Singapore; Ueng-Cheng Yang, National Yang-Ming University, Taipei - Taiwan; Fredj Tekaia, Institut Pasteur Paris, France.

3. Why this course ?

4. 889 65 115 http://www.genomesonline.org/ Tree of life Complete genomes 5207 projects 1069 published (02-08-09) 2755 Bacteria 107 Archaea 1108 Eukaryotes 168 metagenomes 3 phylogenetic domains; Lifestyles: mesophiles; (hyper)thermophiles; psychrophiles; extreme conditions,...

5. Number of completely sequencing genome projects GOLD Completely sequencing Genomes that span the three domains of life are growing at a rapid rate 08-2009 5207 projects

6. Genome studies show that: Access to entire genome sequences has revolutionized our understanding of how genetic information is stored and organized in DNA, and how it has evolved over time. The sequence of a genome provides significant details of the gene catalogue within a species. Comparisons of complete genome sequences show the acceleration in the understanding of species organisation, links between genes, functions of the genes, evolution of genes, genomes and species. => Beyond fundamental biological and methodological interests, Expected applications include: Drug, Medical and Agricultural,… discoveries… and their health and economical concequences.

7. Few scientists are involved in generating data and much more are involved in data analyses

8. Genomics Is the study of genomes. (including the study of their genes, proteins, their sequences, functions, evolution,....)

9. Bioinformatics is needed to transform the flood of raw data (sequences) into scientific knowledge.

10. MathematicsStatistics Nucleotide & protein sequences and related informations Informatics Biology Bioinformatics

11. Information system: http://www.ncbi.nlm.nih.gov Bibliography

12. Bibliography: http://www.ncbi.nlm.nih.gov/PubMed http://www.plosbiology.org

13. The main objectives of the course are to familiarize the selected students with bioinformatics and large scale genome data analyses skills by introducing: 1- advanced fundamental algorithms in Bioinformatics; 2- their application in genome analyses; 3- recent knowledge acquired from genomes studies and their perspectives. Bioinformatics and Comparative Genome Analysis

17. Enjoy this exiting course and your stay in Hong Kong