1. CHAPTER 42 CIRCULATION AND GAS EXCHANGE Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Section A2: Circulation in Animals (continued) 4. Double circulation in mammals depends on the anatomy and pumping cycle of the heart 5. Structural differences of arteries, veins, and capillaries correlate with their different functions

2. In the mammalian cardiovascular system, the pulmonary and system circuits operate simultaneously. The two ventricles pump almost in unison While some blood is traveling in the pulmonary circuit, the rest of the blood is flowing in the systemic circuit. 4. Double circulation in mammals depends on the anatomy and pumping cycle of the heart Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

3. To trace the double circulation pattern of the mammalian cardiovascular system, we’ll start with the pulmonary (lung) circuit. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Fig. 42.4

4. The pulmonary circuit carries blood from the heart to the lungs and back again. (1) The right ventricle pumps blood to the lungs via (2) the pulmonary arteries. As blood flows through (3) capillary beds in the right and left lungs, it loads O 2 and unloads CO 2. Oxygen-rich blood returns from the lungs via the pulmonary veins to (4) the left atrium of the heart. Next, the oxygen-rich blood blows to (5) the left ventricle, as the ventricle opens and the atrium contracts. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

5. The left ventricle pumps oxygen-rich blood out to the body tissues through the systemic circulation. Blood leaves the left ventricle via (6) the aorta, which conveys blood to arteries leading throughout the body. The first branches from the aorta are the coronary arteries, which supply blood to the heart muscle. The next branches lead to capillary beds (7) in the head and arms. The aorta continues in a posterior direction, supplying oxygen-rich blood to arteries leading to (8) arterioles and capillary beds in the abdominal organs and legs. Within the capillaries, blood gives up much of its O 2 and picks up CO 2 produced by cellular respiration. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

6. Venous return to the right side of the heart begins as capillaries rejoin to form venules and then veins. Oxygen-poor blood from the head, neck, and forelimbs is channeled into a large vein called (9) the anterior (or superior) vena cava. Another large vein called the (10) posterior (or inferior) vena cava drains blood from the trunk and hind limbs. The two venae cavae empty their blood into (11) the right atrium, from which the oxygen-poor blood flows into the right ventricle. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

7. The mammalian heart is located beneath the breastbone (sternum) and consists mostly of cardiac muscle. The two atria have relatively thin walls and function as collection chambers for blood returning to the heart. The ventricles have thicker walls and contract much more strongly than the atria. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

8. Fig. 42.5

9. A cardiac cycle is one complete sequence of pumping, as the heart contracts, and filling, as it relaxes and its chambers fill with blood. The contraction phase is called systole, and the relaxation phase is called diastole. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

10. Fig. 42.6

11. For a human at rest with a pulse of about 75 beat per minute, one complete cardiac cycle takes about 0.8 sec. (1) During the relaxation phase (atria and ventricles in diastole) lasting about 0.4 sec, blood returning from the large veins flows into atria and ventricles. (2) A brief period (about 0.1 sec) of atrial systole forces all the remaining blood out of the atria and into the ventricles. (3) During the remaining 0.3 sec of the cycle, ventricular systole pumps blood into the large arteries. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

12. Cardiac output depends on two factors: the rate of contraction or heart rate (number of beats per second) and stroke volume, the amount of blood pumped by the left ventricle in each contraction. The average stroke volume for a human is about 75 mL. The typical resting cardiac output, about 5.25 L / min, is about equivalent to the total volume of blood in the human body. Cardiac output can increase about fivefold during heavy exercise. Heart rate can be measured indirectly by measuring your pulse - the rhythmic stretching of arteries caused by the pressure of blood pumped by the ventricles. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

13. Four valves in the heart, each consisting of flaps of connective tissue, prevent backflow and keep blood moving in the correct direction. Between each atrium and ventricle is an atrioventricular (AV) valve which keeps blood from flowing back into the atria when the ventricles contract. Two sets of semilunar valves, one between the left ventricle and the aorta and the other between the right ventricle and the pulmonary artery, prevent backflow from these vessels into the ventricles while they are relaxing. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

14. The heart sounds we can hear with a stethoscope are caused by the closing of the valves. The sound pattern is “lub-dup, lub-dup, lub-dup.” The first heart sound (“lub”) is created by the recoil of blood against the closed AV valves. The second sound (“dup”) is the recoil of blood against the semilunar valves. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

15. A defect in one or more of the valves causes a heart murmur, which may be detectable as a hissing sound when a stream of blood squirts backward through a valve. Some people are born with heart murmurs. Others are due damage to the valves by infection. Most heart murmurs do not reduce the efficiency of blood flow enough to warrant surgery. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

16. Because the timely delivery of oxygen to the body’s organs is critical for survival, several mechanisms have evolved that assure the continuity and control of heartbeat. Certain cells of vertebrate cardiac muscle are self- excitable, meaning they contract without any signal from the nervous system. Each cell has its own intrinsic contraction rhythm. However, these cells are synchronized by the sinoatrial (SA) node, or pacemaker, which sets the rate and timing at which all cardiac muscle cells contract. The SA node is located in the wall of the right atrium. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

17. The cardiac cycle is regulated by electrical impulses that radiate throughout the heart. Cardiac muscle cells are electrically coupled by intercalated disks between adjacent cells. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Fig. 42.7

18. (1) The SA node generates electrical impulses, much like those produced by nerves that spread rapidly (2) through the wall of the atria, making them contract in unison. The impulse from the SA node is delayed by about 0.1 sec at the atrioventricular (AV) node, the relay point to the ventricle, allowing the atria to empty completely before the ventricles contract. (3) Specialized muscle fibers called bundle branches and Purkinje fibers conduct the signals to the apex of the heart and (4) throughout the ventricular walls. This stimulates the ventricles to contract from the apex toward the atria, driving blood into the large arteries. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

19. The impulses generated during the heart cycle produce electrical currents that are conducted through body fluids to the skin. Here, the currents can be detected by electrodes and recorded as an electrocardiogram (ECG or EKG). Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

20. While the SA node sets the tempo for the entire heat, it is influenced by a variety of physiological cues. Two sets of nerves affect heart rate with one set speeding up the pacemaker and the other set slowing it down. Heart rate is a compromise regulated by the opposing actions of these two sets of nerves. The pacemaker is also influenced by hormones. For example, epinephrine from the adrenal glands increases heart rate. The rate of impulse generation by the pacemaker increases in response to increases in body temperature and with exercise. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

21. All blood vessels are built of similar tissues. The walls of both arteries and veins have three similar layers. On the outside, a layer of connective tissue with elastic fibers allows the vessel to stretch and recoil. A middle layer has smooth muscle and more elastic fibers. Lining the lumen of all blood vessels, including capillaries, is an endothelium, a single layer of flattened cells that minimizes resistance to blood flow. 5. Structural differences of arteries, veins, and capillaries correlate with their different functions Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

22. Structural differences correlate with the different functions of arteries, veins, and capillaries. Capillaries lack the two outer layers and their very thin walls consist of only endothelium and its basement membrane, thus enhancing exchange. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Fig. 42.8

23. Arteries have thicker middle and outer layers than veins. The thicker walls of arteries provide strength to accommodate blood pumped rapidly and at high pressure by the heart. Their elasticity (elastic recoil) helps maintain blood pressure even when the heart relaxes. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings

24. The thinner-walled veins convey blood back to the heart at low velocity and pressure. Blood flows mostly as a result of skeletal muscle contractions when we move that squeeze blood in veins. Within larger veins, flaps of tissues act as one-way valves that allow blood to flow only toward the heart. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Fig. 42.9