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Carbohydrates
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A Few Questions 1) What is the general term used for the simplest carbohydrates? 2) What structural difference is found in the straight chain forms of D-Glucose and D-Fructose? 3) What causes lactose intolerance? 4) What are three differences between glycogen and cellulose? 5) What are lectins and what are some processes they mediate?
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What are Carbohydrates? Polyhydroxy aldehydes and ketones Polyhydroxy aldehydes and ketones usually have “ose” suffix Simple sugars Simple sugarsMonosaccharidesDisacccharides Complex carbohydrates Complex carbohydratesOligosaccharidesPolysaccharides
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Functions of Carbohydrates Stored chemical energy (oxidized to release energy) Stored chemical energy (oxidized to release energy) Component of nucleotides Component of nucleotides nucleic acids – DNA and RNA coenzymes – NADH, coenzyme A……. Structural role (ie cell walls) Structural role (ie cell walls) Linked to proteins and lipids Linked to proteins and lipids cell surface recognition points
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Monosaccharides Foundational building block of carbohydrates Foundational building block of carbohydrates (C-H 2 O) n n = 3-9 typically (C-H 2 O) n n = 3-9 typically “carbon hydrate” Typically D enantiomer Typically D enantiomer What causes this? Why is it important? Straight chain form or cyclic form Straight chain form or cyclic form
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Aldoses (trioses to hexoses)
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Ketoses (trioses to hexoses)
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Pyranose vs Furanose 6 membered ring 5 membered ring
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Forms of D-Glucose
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Forms of D-Fructose
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Cyclic form of D-Ribose
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Glycosidic Bonds
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Sugar Phosphorylation Traps them within the cell (anionic) Makes them more reactive
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Disaccharides Maltose
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Disaccharides
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Lactose Intolerance What is it? What is it? What causes it? What causes it? How do we deal with it? How do we deal with it?
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Polysaccharides - Starch Amylose ( -1,4) Amylopectin ( -1,4 with -1,6 about every 30)
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Polysaccharides - Glycogen ( -1,4 with -1,6 about every 10)
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Polysaccharides - Cellulose ( -1,4 linkages giving a very linear structure) Dietary fiber
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Glycoproteins O-linked vs N-linked
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Lectins Mediate cell-cell interaction (ie in development and wound healing)
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Lectins can mediate bacterial and viral infection
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Selectins L – on lymphocytes and mediate binding to lymph node vessels (also mediate embryonic implantation) E – on circulating cells binding to endothelium P – on activated blood platelets
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