1. Réponse non spécifique ou innée (2h) Les cellules Natural Killers et leurs déficits (1h) : Cellules NK & Immunité Innée vivier@ciml.univ-mrs.fr

2. Part I. Innate Immunity

4. Innate + adaptive immunity Innate immunity only From Thomas C. G. Bosch (Kiel)

5. Histoire dune découverte « The dirty little trick »

6. A paradigm: Self vs. Non-self « The structure of scientific revolutions » Thomas S. Kuhn 1962 - « Their achievement was sufficiently unprecedented to attract an enduring group of adherent away from competing modes of scientific activity » - « Simultaneously, it was sufficiently open-ended to leave all sorts of problems for the redefined group of practitioners to resolve »

7. Paradigm shift: Une expérience simple

8. Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13. Approaching the asymptote? Evolution and revolution in immunology.

9. Insects have an open circulatory system Brain Gut Dorsal blood vessel Nervous chain Hematopoietic tissues Viruses Bacteria Fungi Protozoa

10. Induction of antimicrobial activity by immune challenge Injection of bacteria ControlAntimicrobial activity in the cell-free hemolymph Time (h) 069 1224 48 3