1. Lecture 12 August 26, 2005 Lehninger (4 th Edition), Chapter 17

3. FATTY ACID DEGRADATION (OXIDATION) LNC Chapter 17

6. LNC 10-1

7. LNC 10-6

8. LNC 10-8

9. LNC 10-15

10. LNC 10-16

11. UPTAKE and DISTRIBUTION in Mammals

12. LNC 17-1

13. LNC 21-40 ADIPOSE TISSUE

14. LNC 17-2 Chylomicron

15. LNC 21-39a Structure of an LDL particle

16. LNC 21-39b

17. Breakdown/Oxidation of Fatty Acids  -Oxidation

18. Activation LNC 17-5

19. LNC 17-6

20. C 14 fatty acid 7 acetyl CoA 6 rounds of  oxidation

21. LNC 17-7

22. LNC 19-8

23. LNC 17-9 How to deal with unsaturated fatty acids: cis  3 - or double bond between 

25. LNC 17-10

26. LNC 17-11 How to deal with a fatty acid containing an uneven number of carbons C3 C4

27. LNC box 17-1

28. LNC box 17-2

31. catalase Degradation of very long chain fatty acids in the peroxisome LNC 17-12

32. Glyoxalate Cycle in Plants LNC 17-13

33. Ketone Bodies

34. LNC Fig 17-18 Conditions favoring ketone body formation: depletion of OA for gluconeogenesis acetyl-CoA becomes available for ketone body synthesis

35. Metabolic Biochemistry FATTY ACID SYNTHESIS LNC Chapter 21

36. LNC Fig. 21-1 the enzyme has three functional regions: - biotin carrier protein - biotin carboxylase - transcarboxylase acetyl-CoA + CO 2 ==> malonyl-CoA

37. LNC Fig. 21-4

38. acyl carrier protein LNC Fig. 21-2

39. End of lecture 12 August 26, 2005