1. Pediatric Behavioral Epidemiology Xinguang (Jim) Chen, MD, PhD Pediatric Prevention Research Center jimchen@med.wayne.edu

2. Behavior, Morbidity and Mortality  Rates of disease morbidity and premature mortality reflect people's behavioral practices (Healthy People 2010).  Substance use: Tobacco, alcohol and illegal drugs  HIV risk behaviors: Sexual risk, needle sharing,  Physical activity: Overweight/obesity, mental health  Eating behavior: Nutrition and metabolic syndrome

3. Why Epidemiology?  To grasp a fuller picture of an issue (including, tobacco exposure, asthma, obesity, leukemia, etc)  To detect disease etiology at various levels, ranging from molecular, genetic, to behavioral, environmental & social  To take measures for health promotion and disease prevention at group levels (e.g., tobacco control campaigns, vaccination programs, etc)  To understand mechanisms involved in behavioral change (e.g., dynamic progression), disease spreading and disease prevention (e.g., Herd immunity) via modeling analysis.

4. Geographic Distribution of Obese Children 3-5 Years Old from Low Income Families 2006-08 Data source: CDC Pediatric Nutrition Surveillance System (PedNSS)

5. Trends in the Prevalence of Obesity ( BMI>95 th Percentile ) in Pre-School Children (2-5 Years Old) Data source: CDC Pediatric Nutrition Surveillance System (PedNSS)

6. Trends in the Prevalence of Obesity (BMI≥30) among US Adults (20-39 Years Old) Created using data from: Flegal et al, JAMA, 2010, 303 (3): 325-241 Original data: The National Health and Nutrition Examination Survey (NHANES)

7. Changes in Smoking Behavior During Pregnancy Among Smoking Mothers (N=160) Data source : Chen & Woodcroft, 2009, Nicotine and Tobacco Research, 11(3): 225-33

8. Polymorphic CYP2A6 and Changes in Maternal Smoking Behavior During Pregnancy Data source : Chen & Woodcroft, 2009, Nicotine and Tobacco Research, 11(3): 225-33

9. Questions and Answers  Thank You