1. (-)-Kendomycin 2009.05.18 Angew. Chem. Int. Ed. 2009,48,()

2. 1. Macrocyclic polyketide isolated from different Streptomyces species in 1996. 2. Endothelin receptor antagonist. 3. Antiosteoporotic agent. 4. Remarkable antibacterial (MRSA) and cytostatic activity. 5. Four total synthesis and one formal synthesis

10. Seyferth-Gilbert homomogation J. Chem. Soc. Chem. Commun. 1973, 151.

11. Schwartz Hydrozirconation

12. Fries-, photo-fries and anionic ortho-fries rearrangement

13. J. Org. Chem., 1997, 62 (19), 6547-6561

18. Amos B. Smith, 3. J. AM. CHEM.SOC.2005,127,6048-6949 2006,128,5292-5299

19. Chulborn Lee. J. AM. CHEM. SOC. 2004, 126, 14720-14721

21. OL, 10(17), 3813-3816

22. J. Am. Chem. Soc., Vol. 122, No. 40, 2000, 9837

23. Barbier coupling reaction

24. Scott D. Rychnovsky J. AM. CHEM. SOC. 2008, 130, 13177–13181

26. Chem. Commun., 2006, 2388–2390

27. 谢谢 !