1. Non Homologous End Joining

3. Homologous Recombination Non Homologous End Joining

6. Differences between HR and NHEJ: Error- free / Error- prone Cell cycle regulated Varies between species HR NHEJ yeastmammals plants

7. HRNHEJ MHC rearrangement Meiosis Cell-induced Double Strand Brakes

8. V(D)J recombination

9. NHEJ Defects SCID (Severe Combined Immune Deficiency). Cancer – genome instability: rearrangements, deletions, amplifications.

10. Ku 70/80 heterodimer

11. Ku has a role in telomeres ?

12. KU 70/80

13. Ku is critical for telomere maintenance

14. Ku Plays Several Roles at Telomeres Telomere addition Telomeric silencing

15. Ku is a multifunctional protein

16. The Role of NHEJ Proteins in Telomere Biology

17. Visualization of single double- strand brake

18. HR NHEJ