1. Harvard Catalyst: How Can It Help Your Research? Steven D. Freedman MD PhD Professor of Medicine, HMS Associate Dean for Clinical and Translational Research, HMS Co-Director, Harvard Catalyst Chief, Division of Translational Research, BIDMC Director, The Pancreas Center, BIDMC

2. “The purpose of this initiative is to assist institutions to create a uniquely transformative, novel, and integrative academic home for the Clinical and Translational Science that has the resources to train and advance a cadre of well-trained multi- and inter- disciplinary investigators and research teams with access to innovative research tools and information technologies to promote the application of new knowledge and techniques to patient care.” CTSC 2007 RFA

3. Harvard Catalyst: The Basics $192 million infrastructural organization designed to support, enhance and catalyze translational research across all of Harvard and its 18 affiliated hospitals and institutions: –Bring people together (CONNECTIONS) –Lower barriers to research such as the duplicative IRB submissions and restricted access to cores (AT THE CUTTING EDGE) –Enhance the pipeline of researches (NURTURING)

4. Beth Israel Deaconess Medical Center Brigham and Women’s Hospital Massachusetts General Hospital Children’s Hospital Boston Dana-Farber Cancer Institute Forsyth Institute Joslin Diabetes Center Massachusetts Eye and Ear Infirmary McLean Hospital Schepens Eye Research Institute Harvard University Faculty of Arts and Sciences Harvard Business School Harvard School of Dental Medicine Harvard Divinity School Harvard Graduate School of Education Kennedy School of Government Harvard Law School Harvard Medical School Harvard School of Public Health Harvard School of Engineering and Applied Sciences Radcliffe Institute for Advanced Study 25+ Institutions Participate in the Harvard CTSC Massachusetts Institute of Technology Boston College Cambridge Health Alliance HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare

5. Harvard Catalyst Programs 1. Development of Novel Methodologies; Linkages (V. Sukhatme, Ava Guinan) 2. Pilot Studies (L. Nadler) 3. Informatics (I. Kohane) 4. Biostatistics (J. Ware) 5. Research Ethics (D. Brock) 6. Regulatory Knowledge and Support (B. Bierer) 7. Participant and Clinical Interactions Resource (A. Klibanski) 8. Community Engagement (R. Platt) 9. Translational Technologies (Imaging, Genetics/Genomics) (G. Williams) 10. Research Education, Training and Career Development (D. Golan, E. Antman) 11. Diversity (J. Reede) 12. Health Disparities Research (J. Ayanian)

6. Harvard Catalyst: Initial Launch September 2008 CONNECTS –Web portal: http://catalyst.harvard.eduhttp://catalyst.harvard.edu –Find People, Learning, Access Resources Pilot Funding –$3.1M in 2008 to support innovative, inter-disciplinary, or cross institutional research –Now on Round 3 GCRCs –Transform into CRCs without walls –Develop common core lab Regulatory –Reliance agreement (single IRB concept) Consult Services –Biostatistics, Genetics/Genomics, Imaging

7. Introductory Introduction to Clinical Investigation T1 Translational Summer Course Summer Clinical Effectiveness Course Advanced Courses Searchable catalogue Compendium Masters, KL2 2 yr advanced programs Masters in Med. Science CITP, Scholars in Clinical Science, MPH, Masters in Bioinformatics, Masters in Global Health Integrated Consultative Program Education

8. R01 or Equivalent Mentorship Young People Applying for Grants Applying for K, R, or equivalent grant Grant Review Program Review project timelines Critique grant application May recommend specific experts Team approach Problems Darwinian environment Gender/racial disparities No team approach

9. http://catalyst.harvard.edu/