1. Enzymes 2 nd Year Dentistry By Eman Mokbel Alissa, Ph.D.

2. Lecture (1): Lecture Content Enzyme Definition Enzymes vs. biological catalysts Enzyme Nomenclature –Recommended name and IUBMB system Enzyme Classification –Simple and complex enzymes

3. Lecture (2): Lecture Content Coenzymes Properties of enzymes: 1.Catalytic efficiency 2.Location within cell 3.Enzyme active site 4.Specificity 2 hypothesis of enzyme specificity

4. Lecture (3): Lecture Content Mechanism of enzyme action Mechanism of enzyme catalysis The Enzyme Substrate Complex Factors Affecting Reaction Velocity

5. Lecture (4): Lecture Content Enzymes Kinetics Michaelis-Menten equation Linweaver-plot Types of Enzyme Specificity Mechanisms of enzyme catalysis

6. Lecture (5): Lecture Content Enzymes Inhibitors: –Reversible and irreversible –Competitive and uncompetitive Medical relevance of enzyme Inhibitors Antibiotics Enzymes Clinical Application

7. Lecture (6): Lecture Content Common Terminology Allosteric enzymes Allosterism vs. cooperativity Allosteric Enzymes Kinetics Feed back inhibition Homotropic and Heterotropic effectors Enzyme Activity Regulation 1.Induction and repression 2.Covalent modification 3.Compartmentalization

8. Lecture (7): Lecture Content Enzyme measurements Plasma Enzymes Serum enzymes in Diagnosis Isoenzymes