1. Computing in the Life Sciences Stephen Emmott Microsoft Research Cambridge

2. Context:

3. ‘New kinds’ of science

4. What we are doing:

5. Inventing and building new kinds of tools pioneering new kinds of science

6. Integrate theoretical, experimental, computational science

7. 1:Revolutionising biological modelling

8. Codification of biology: 4 letters [genome] > 20 letters +3D position [proteome] > networks [pathways] > processes [e.g. immune system]

9. Process calculi:  -calculus: Tool=SPiM

10. Compositionality, parallelism, abstraction: a language for programming biology

11. P-system models, beta-binders [apoptosis]

12. Artificial biochemistry > library of gene gates > artificial complex biological systems: Enabling new kind of in-silico biology

13. 2:Advancing immunology

14. MHC Antigen presentation

15. 3:Understanding Earth’s life Support System

16. Integrating climate models, oceanography, biodiversity science, theoretical ecology

17. [Building blocks of] New kinds of computing:

18. Lessons from Nature: biochemistry, proteins, immunology, morphogenesis...

19. Other / New projects:

20. MToR, Food-webs, Highly novel bio-energetic models, Molecular computing:‘informed matter’

21. Conclusions: just beginning, exciting times

22. semmott@microsoft.com

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