1. Materials and Engineering Science ANSTO website:http://www.ansto.gov.au/ansto/matengsci/index.html Suzanne V Smith svs@ansto.gov.au

2. Radioanalytical and Chemical Analysis Expertise Experience in development of targetry, design and execution of radiotracer studies. Development of routine methods and training in use of relevant techniques is also available.

3. Radioanalytical and Chemical Analysis Facilities Gamma counter –(0 - 2000 keV; small and large sampling) Alpha, beta and gamma spectrometry –(28 and 50% efficiency) Graphite furnace atomic absorption spectroscopy Inductively coupled plasma-mass spectrometry (ICP-MS), and Clean room facilities.

4. Nanotechnology Controlled Release of Drugs. ≈ 20  m Novel technology for production nanoparticles. Encapsulation and release of molecules under controlled conditions ≈ 0.05  m Selective Inorganic Sorbents Microporous inorganic adsorbents that have unique metal ion binding affinity. Investigating their application for radioisotope separation. Images: Alexandra Bush Image: Victor Luca

5. Microbiology Research/synthesis of bio-inorganic composites (live rocks). Characterisation of biological systems. Culturing of fastidious microbes - magnetotactic bacteria Novel bioreactors – culturing cells requiring high pO 2 –E.g hepatocytes Top: magnetotactic bacterium with a chain of magnetosomes (dark inclusions). Bottom: higher magnification of the magnetosomes in the cell. Images from Tony Taylor

6. Integrated Suite of Characterisation Capabilities and Expertise Scanning electron microscopy (SEM) spatial/topological info., resolution 3.5 nm chemical info., spatial limit ~1 micron Transmission electron microscopy (TEM) spatial/structural/topological info., resolution 0.1 nm chemical/valence/bonding info., spatial limit ~10 nm Structure and texture analysis X-ray diffraction (XRD) Neutron diffraction Nuclear Magnetic Resonance Spectroscopy (NMR) Atomic force microscopy (AFM)

7. International Collaborations Radiometal tracers Apply ANU/ANSTO patent - radiolabelling technology –Harvard Medical School, USA – Humanized Antibodies –Cambridge University, UK – Humanized Antibodies –TRIUMF, Canada – RNA Apply ANSTO Radioplatinum Patent Technology –Paterson Cancer Institute, UK –Harvard Medical School, USA –NECSA, South Africa