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S-Adenosylmethionine (SAM) Is Generated from the S N 2 Reaction of Methionine and ATP Methionine adenosyl transferase Driving force for the reaction is.

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Presentation on theme: "S-Adenosylmethionine (SAM) Is Generated from the S N 2 Reaction of Methionine and ATP Methionine adenosyl transferase Driving force for the reaction is."— Presentation transcript:

1 S-Adenosylmethionine (SAM) Is Generated from the S N 2 Reaction of Methionine and ATP Methionine adenosyl transferase Driving force for the reaction is subsequent hydrolysis of triphosphate S N 2 reaction adenosine triphosphate (ATP) methionine S-adenosylmethionine (SAM)

2 S-Adenosylmethionine (SAM) Is A Biological Methylating Agent SAM-dependent methyl transferases O-, S-, and N-Methylation N-methylation: DNA and tRNA bases, amine side chains in proteins O-methylation: protein carboxylates, polysaccharide alcohols, neurotransmitter phenols S-methylation: Thiols S N 2 reaction

3 SAM at Work…

4 Methylation of Norepinephrine to Epinephrine by SAM and PNMT Phenylethanolamine- N-methyl transferase (PNMT) Adrenal cortex SAM norepinephrine Epinephrine (adrenalin)

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