1. The Acute Phase Response Activated in response to “alarm” cytokines: IL-1, IL-6. Enhances host resistance, minimizes tissue injury, promotes resolution and repair of inflammatory lesion.

2. The Inflammatory Response Produced through: (I) Ab Independence (a) Tissue Injury (b) Alternate complement pathway (II) Ab Dependence (a) Classical complement (b) Mast cell degranulation

3. Mediators of Inflammation

4. Mast Cell Mediators

5. Chemokines` Function: Stimulates chemokinesis and chemotaxis (a chemotactic cytokine.) Two types: –C-C (produced mainly by activated T cells - acts mainly on subsets of m/p’s and T H cells). e.g. RANTES –C-X-C (produced mainly by m/p’s, endothelial cells, fibroblasts - acts mainly on neutrophils). e.g. IL-8

7. The Complement Pathway

8. Biological Functions of Complement

9. Biological Functions of Macrophages Phagocytosis Antigen-presenting cell Cytokine production

10. Innate vs Acquired Immunity

11. Innate-Adaptive Immunity

12. The Antiviral Response

13. Fc Receptors

14. Antiviral Immunity

15. TNF 

16. Delayed-Type Hypersensitivity I

17. T Cell Receptor

18. Mechanism of T Cell Triggering

19. Successful Effector Cell Stimulation Requires Accessory Molecules

20. T H 1 vs T H 2