Download presentation
Presentation is loading. Please wait.
2
Louis Pasteur watches a rabies vaccination
3
Immunity: 2 Branches 1. Non-specific Immunity 2. Specific Acquired Immunity Examples? Specific Has memory
4
Macrophage attacking E. coli RBC monocyte
5
Adaptive Immunity: 2 Branches HumoralCell-mediated
6
T-lymphocyte interacting with a macrophage
7
Overview of Immune System
9
Response to Ag (humoral system)
10
Generic Ab
11
Ribbon diagram of a monoclonal ab
12
Variability of residues in different abs. The 3 hypervariable regions are termed complementarity- determining regions (CDR)
13
Side-view of Angiotensin II bound to F ab. Van der Waals surface contacts
14
A peptide fomr the HIV protease with an anti-protease F ab
17
H-gene expression
18
Recombination signal sequences
25
Animation http://vcell.ndsu.nodak.edu/animations/mrnasplicing/advanced.htm
26
Secretory pathway
28
The Ig superfamily
30
Cells of the Immune System
31
3.7 x 10 11 cells produced/day!
32
Lymphocytes (derived from lymphoid progenitor) Large, granular
34
(e.g. a macrophage)
35
T-cell Ag-presenting macrophage
36
Subtractive Hybridization Why? 98% of gene expression is the same in B and T cells Rearranged DNA Search for the TCR
39
Gene rearrangements yield a functional TCR.
40
Rearranged genes
42
Ig domains TCR accessory proteins
47
Base pairing between U1 snRNA and the 5’ splice site of an mRNA precursor is necessary but not sufficient for splicing to occur.
48
The U2 snRNP associates with the 5’-end of the intron by base pairing prior to lariat formation. U6 also associates with U2 (not the band). U2 base-pairs with the conserved sequence at the splice branch point and with U6.
53
Animation http://vcell.ndsu.nodak.edu/animations/mrnasplicing/advanced.htm
64
cis-acting sites
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.