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Louis Pasteur watches a rabies vaccination Immunity: 2 Branches 1. Non-specific Immunity 2. Specific Acquired Immunity Examples? Specific Has memory.

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Presentation on theme: "Louis Pasteur watches a rabies vaccination Immunity: 2 Branches 1. Non-specific Immunity 2. Specific Acquired Immunity Examples? Specific Has memory."— Presentation transcript:

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2 Louis Pasteur watches a rabies vaccination

3 Immunity: 2 Branches 1. Non-specific Immunity 2. Specific Acquired Immunity Examples? Specific Has memory

4 Macrophage attacking E. coli RBC monocyte

5 Adaptive Immunity: 2 Branches HumoralCell-mediated

6 T-lymphocyte interacting with a macrophage

7 Overview of Immune System

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9 Response to Ag (humoral system)

10 Generic Ab

11 Ribbon diagram of a monoclonal ab

12 Variability of residues in different abs. The 3 hypervariable regions are termed complementarity- determining regions (CDR)

13 Side-view of Angiotensin II bound to F ab. Van der Waals surface contacts

14 A peptide fomr the HIV protease with an anti-protease F ab

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17 H-gene expression

18 Recombination signal sequences

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25 Animation http://vcell.ndsu.nodak.edu/animations/mrnasplicing/advanced.htm

26 Secretory pathway

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28 The Ig superfamily

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30 Cells of the Immune System

31 3.7 x 10 11 cells produced/day!

32 Lymphocytes (derived from lymphoid progenitor) Large, granular

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34 (e.g. a macrophage)

35 T-cell Ag-presenting macrophage

36 Subtractive Hybridization Why? 98% of gene expression is the same in B and T cells Rearranged DNA Search for the TCR

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39 Gene rearrangements yield a functional TCR.

40 Rearranged genes

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42 Ig domains TCR accessory proteins

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47 Base pairing between U1 snRNA and the 5’ splice site of an mRNA precursor is necessary but not sufficient for splicing to occur.

48 The U2 snRNP associates with the 5’-end of the intron by base pairing prior to lariat formation. U6 also associates with U2 (not the band). U2 base-pairs with the conserved sequence at the splice branch point and with U6.

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53 Animation http://vcell.ndsu.nodak.edu/animations/mrnasplicing/advanced.htm

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64 cis-acting sites


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