1. Chem 509 Signal Transduction Winter 2010 Lecture 1

4. 6 general classes of receptors

5. Ligand, agonist, antagonist

6. Autocrine, paracrine, endocrine: three mechanisms of signaling cells

7. Fight or Flight Response http://monmouthfamilywellness.com/yahoo_site_admin/assets/images/fight-or-flight.107165735_std.jpg

14. Cholera Vibrio cholerae http://geo.arc.nasa.gov/sge/health/sensor/diseases/cholera.html http://blackminis.wordpress.com/2008/ 12/12/winter-brings-infection/

17. AKAP: A kinase anchoring protein Protein Kinase A

21. Termination of beta adrenergic signaling pathway: 1.Epinepherine concentration is lowered. 2.GAP activity of Gs alpha (GTP converted to GDP) 3.cAMP phosphodiesterase 4.Phosphorylation of beta-adrenergic receptor - kinase is beta-adrenergic receptor kinase(BARK) -also known as G protein-coupled receptor kinase 2 5.Association of phosphorylated beta-adrenergic receptor with arrestin. This is followed by receptor endocytosis.

22. End of Lecture 1