1. Chapter 3 SIMILARITIES AND DIFFERENCES BETWEEN CELLS

2. Selectivity We are a community of living creatures (cells) in a “pond of water” –Specialized members of the community –Outlaw cells (cancer) –Invaders

3. Blood Stream Each group of cells have unique barriers (capillaries) for exchange with the blood which allows them to create a special environment for that group of cells

4. Different Cell Types Common Processes: Processes all cells must do. Qualitative Differences: Unique processes that all types of cells do not do Quantitative differences: Some cells do more or less of some processes

5. Energy The production of high potential energy molecules such as ATP All cells need to do this

6. Cell Types Differ in their use of Energy Glucose + 2 ADP + 2 Pi + 2 NAD+ ---> 2 Pyruvate + 2 ATP + 2 NADH + 2 H+ + 2 H 2 O Small amount of energy (ATP) Acetyl-CoA + 3 NAD+ + FAD + GDP + Pi + 3 H 2 O ---> 3 NADH + FADH2 + CoA-SH + GTP + 3 CO 2 Large amount of energy Without Oxygen With Oxygen Use of Fat and pyruvate Use of Sugar

7. Variation in energy Extremes in energy use Skeletal muscle. Brain

8. Reproduction (Stem Cells) Skin and lining of digestive system (replacement) Liver and muscle (damage) Immune system (replacement and attack) Nervous system ???

9. Cell Division (proliferation) A complex process involving many reactions (proteins) Signals for and against –Inhibition –Stimulation Copy DNA (check for mistakes: repair or apoptosis) Mutations: mistakes that escape Separate into two cells

10. Protein Synthesis and Degradation Both Carried out by proteins Synthesis depends on mRNA Degradation depends on proteins Highly controlled and selective

11. Turnover

12. The Cell Membrane Charge barrier Molecular ports (channels) Information ports (receptors) They often work together

13. The cell

14. Channels Ion channel Glucose channel

15. Relationships between Cells Communications: a language of chemical messages Coordinates functions involving many cells Signals and Receptors: A cell can’t respond to a signal that it can’t see

16. Signals Chemical messages made by one cell that gives directions to another cell or cells Two types: water soluble and fat soluble –Insulin –Glucocorticoids Frequency and intensity modulated signals Every hormone is a different “voice” talking to those cells in the community that can listen

17. Receptors A cell can only respond to the “voices” that it can hear Receptors mediate many things –Open channels through the membrane –Alter gene expression –Signals often cascade and feedback

18. Receptors Ion channel in center

19. Receptors Respond to the signal Adjust and remember Tolerance Dependence

20. Other Forms of Life in the Community Viruses Bacteria Fungi Parasites