2. Skeletal Skeletal – striated, multinucleate, voluntary, 10-100  m Smooth Smooth - found in walls of hollow visceral organs; ex. stomach, bladder, respiratory passages; visceral, nonstriated, involuntary; discuss peristalsis Cardiac Cardiac – in heart only, striated, involuntary, intercalcated disks

3. Muscle function: produce movement maintain posture stabilize joints generate heat move substances within the body

4. Functional Characteristics: Excitability- respond to a stimulus Contractility- ability to shorten forcibly when adequately stimulated Extensibility- the ability to be stretched Elasticity- the ability of a muscle fiber to resume its resting length after being stretched

5. Skeletal Muscle Tissue

6. Smooth Muscle Tissue

7. Cardiac Muscle Tissue

8. Skeletal Muscle b Connective tissue sheaths of skeletal muscle: Epimysium: dense regular connective tissue surrounding entire muscleEpimysium: dense regular connective tissue surrounding entire muscle Perimysium: fibrous connective tissue surrounding fascicles (groups of muscle fibers)Perimysium: fibrous connective tissue surrounding fascicles (groups of muscle fibers) Endomysium: fine areolar connective tissue surrounding each muscle fiberEndomysium: fine areolar connective tissue surrounding each muscle fiber

9. Figure 9.1 Bone Perimysium Endomysium (between individual muscle fibers) Muscle fiber Fascicle (wrapped by perimysium) Epimysium Tendon Epimysium Muscle fiber in middle of a fascicle Blood vessel Perimysium Endomysium Fascicle (a) (b)

10. bundle of muscle fibers muscle fiber (cell) myofibril sarcomere Muscle Anatomy

11. Muscle Fiber

12. Myofibril

13. Sarcomere Z lines

14. Sarcomere A band

15. Sarcomere I bands

16. Sarcomere H zone

17. Actin and Myosin Filaments myosin actin

18. Myosin (Thick) Filament

19. Actin (Thin) Filament

20. Sliding Filament Hypothesis A Z Z H I I A I I Z Z H Z Z H A I I

21. Actin (Thin) Filament No Calcium Ion tropomyosin troponin

22. Actin (Thin) Filament Calcium Ion Present tropomyosin myosin binding sites

23. Actin & Myosin Interaction

24. Biology 100 Human Biology Motor Unit spinal cord motor neurons muscle bundle muscle fibers neuromuscular junctions

25. Neuromuscular junctions branching axon to motor unit muscle fibers

26. Axon (motor neuron) sarcolemma myofibrils sarcomere sarcoplasm Sarcoplasmic Reticulum Neuromuscular junction

27. T tubules sarcoplasmic reticulum http://www.blackwellpublishing.com/matthews/myosin.html

28. Stimulation of Skeletal Muscle

29. Figure 9.9 Na + Open Na + Channel Closed Na + Channel Closed K + Channel Open K + Channel Action potential + + ++ + + + + ++ + + Axon terminal Synaptic cleft ACh Sarcoplasm of muscle fiber K+K+ 2 Generation and propagation of the action potential (AP) 3 Repolarization 1 Local depolarization: generation of the end plate potential on the sarcolemma K+K+ K+K+ Na + K+K+ W a v e o f d e p o l a r i z a t i o n

30. Figure 9.9, step 1 Na + Open Na + Channel Closed K + Channel K+K+ Na + K+K+ Action potential + + + + + + + + + + + + Axon terminal Synaptic cleft ACh Sarcoplasm of muscle fiber K+K+ 1 Local depolarization: generation of the end plate potential on the sarcolemma 1 W a v e o f d e p o l a r i z a t i o n

31. Figure 9.9, step 2 Na + Open Na + Channel Closed K + Channel K+K+ Na + K+K+ Action potential + + + + + + + + + + + + Axon terminal Synaptic cleft ACh Sarcoplasm of muscle fiber K+K+ Generation and propagation of the action potential (AP) 1 Local depolarization: generation of the end plate potential on the sarcolemma 2 1 W a v e o f d e p o l a r i z a t i o n

32. Figure 9.9, step 3 Na + Closed Na + Channel Open K + Channel K+K+ Repolarization 3

33. Figure 9.9 Na + Open Na + Channel Closed K + Channel Action potential + + ++ + + + + ++ + + Axon terminal Synaptic cleft ACh Sarcoplasm of muscle fiber K+K+ 2 Generation and propagation of the action potential (AP) 3 Repolarization 1 Local depolarization: generation of the end plate potential on the sarcolemma K+K+ K+K+ Na + K+K+ W a v e o f d e p o l a r i z a t i o n Closed Na + Channel Open K + Channel

34. Figure 9.10 Na + channels close, K + channels open K + channels close Repolarization due to K + exit Threshold Na + channels open Depolarization due to Na+ entry

35. Stimulation of Skeletal Muscle

42. Relaxation of Skeletal Muscle

43. Stimulation of Skeletal Muscle

45. Muscle Twitch

46. Contraction Response single twitches wave summation tetanus action potentials in motor neuron

47. Isotonic and Isometric Contractions Isotonic contraction Contraction with a change in length The muscle shortens and movement occurs. Isometric contraction Contraction without any change in length The muscle does not shorten and there is no movement produced even though the muscle contracts.

48. Isotonic and Isometric Contractions Isotonic Isometric

49. Slow-Twitch Versus Fast-Twitch Muscle Fibers

50. ATP is Generated by: 1.creatine phosphate ADP + creatine phosphate  creatine + ATP 2. lactic acid fermentation From stored glycogen via anaerobic glycolysis; glucose  pyruvic acid (no O 2 )  lactic acid  O 2 3. aerobic respiration Krebs  CO 2 + H 2 O + ATP Energy for muscle contraction: ATP is the only energy source ATP  (ATPase + H 2 O)  ADP + Pi

51. Muscle Fiber Types Fast glycolitic Slow oxidative Fast oxidative-glycolytic Ratio- red:white (all 3 types in body)

52. Fast glycolitic: white muscle fibers low myoglobin anaerobic glycolysis few mitochondria fast twitch fibers high glycogen stores short bursts fatigues easily

53. Slow oxidative: red muscle aerobic high myoglobin low glycogen stores lots mitochondria slow tonic long distance

54. Fast oxidative-glycolitic: red  pink Aerobic & anaerobic fast high myoglobin intermediate amt. of mitochondria intermediate glycogen intermediate fatigue resistance

55. Tuna- long distance swimmer Snapper- short bursts

56. Sprinter- anaerobic respiration Long distance Runner- aerobic respiration

57. Smooth Muscle Fibers Mainly aerobic Arranged in opposing sheets

58. Smooth Muscle Fibers peristalsis

59. Cardiac Tissue More mitochondria Longer refractory period Mainly aerobic respiration Can use multiple fuel molecules

60. Effects of Exercise Hypertrophy- excessive enlargement of muscle tissue Atrophy- disuse Muscles must be physically active if they are to remain healthy Cast Cast- muscle strength can decrease at a rate of 5%/ day; can use e- stimulus Avoid muscle injuries: -warm up muscles- walk fast 5 minutes -then stretch- avoids pulls and tares

61. Steroids Anabolic steroids similar to testosterone large doses required for good effect Side effects: overall - kidney and heart damage, aggressiveness females - sterility, facial hair, breast & uterine atrophy males - baldness, atrophy of testis

62. cramp- sustained spasm or tetanic contraction; may be due to low blood sugar levels, electrolyte depletion, dehydration how to care for cramp: RICE strain- muscle pull spasm- tics hernia- protrusion of organ through body cavity wall  may be due to heavy wts. Muscle Disorders

63. Inquiry 1.What is stored in SER? 2.Which protein blocks the heads of myosin? 3.When a neuron synapses with a muscle it is called---. 4.The neuron going to a muscle is called ____. 5.A muscle that shortens or lengthens is called ____. 6.Which ion floods into the sarcolemma after stimulation by a neuron? 7.Which neurotransmitter binds to the sarcolemma? 8.Which type of muscles undergo aerobic respiration? 9.Which type of fuel is stored in muscle tissues? 10.Which pigment is stored in muscles that has a high affinity for oxygen? 11.Which muscle tissue has intercalated discs? 12.What is depolarization?