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Division of Genetic and Reproductive Toxicology Staff Research Focus Areas Senior Investigators Framework for Research.

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Presentation on theme: "Division of Genetic and Reproductive Toxicology Staff Research Focus Areas Senior Investigators Framework for Research."— Presentation transcript:

1 Division of Genetic and Reproductive Toxicology Staff Research Focus Areas Senior Investigators Framework for Research

2 DGRT Staff 31.8 FTE Government positions 14 Research Scientists 3 Staff Fellows 12.8 Support Scientists 2 Administrative 6 ORISE Post Docs 1 ORISE Pre Doc

3 DGRT Research Focus Areas Genetic Toxicology Reproductive/ Developmental Toxicology Diet and Nutrition Genomics & Proteomics

4 Senior Investigators-- Genetic Toxicology In vivo: Bob Heflich Ben Aidoo Tao Chen* Vasily Dobrovolsky* Jim Fuscoe Magomed Khaidakov** Manju Manjanatha Page McKinzie** Suzanne Morris Barbara Parsons* Carrie Valentine In vitro: Suzanne Morris Tao Chen* Bruce Hass TBN** * Staff Fellow ** Post Doc

5 Senior Investigators-- Reproductive/Developmental Toxicology Deb Hansen Bill Branham Ming Lu Dan Sheehan

6 Senior Investigators--Diet and Nutrition Ritchie Feuers Peter Duffy Varsha Desai** Ming Lu Ben Aidoo Deb Hansen Bob Heflich Sachin Bendre*** Suzanne Morris ** Post Doc ***Pre Doc

7 Senior Investigators-- Genomics and proteomics Jim Fuscoe Ritchie Feuers Angela Harris Varsha Desai** Suzanne Morris ** Post Doc

8 Framework for DGRT Research Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) Chemical Specific Information CFSAN CDER CBER CVM CDRH OWH

9 Framework for DGRT Research Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) --Hazard Characterization --Dose Response Assessment

10 Framework for DGRT Research Hazard Characterization --Develop new methods --Characterize/understand assays --Interpretation of data --Modes of action for toxicants --Rodent/human extrapolation --Develop guidelines

11 Framework for DGRT Research Hazard Characterization --Develop new methods TK+/- Mouse Model MutEx/ACB-PCR Genotypic Selection PhiX174 Gene Mutation Keratinocyte hprt Fluorescent Markers Endocrine Knowledge

12 Framework for DGRT Research Hazard Characterization --Characterize/understand assays --Interpretation of data In Vivo lacI and hprt Mouse Lymphoma TK Assay In Vivo Mouse TK Assay Human Lymphoblastoid TK Assay Filter Arrays

13 Framework for DGRT Research Hazard Characterization --Modes of action for toxicants DNA Sequence Analysis Chromosomal Mutations Genomic Rearrangements Folate & Neural Tube Development Impact of Dietary Restriction on Somatic Mutation and Physiological Parameters Gene Expression & Protein Production

14 Framework for DGRT Research Hazard Characterization --Rodent/human extrapolation Response to Dietary Restriction & Nutritional Changes Response of Hepatocytes to Toxicants

15 Framework for DGRT Research Mouse Lymphoma TK Assay In Vivo Gene Mutation Assays Hazard Characterization --Develop guidelines

16 Framework for DGRT Research Dose Response Assessment --Relevant doses --Susceptibility/variability --Rodent/human extrapolation --Cancer/noncancer --Quantitative models

17 Framework for DGRT Research Dose Response Assessment --Relevant doses Dose Selection Biomarkers Genomics/Proteomics

18 Framework for DGRT Research Dose Response Assessment --Susceptibility/variability Fetus/Newborn/ Young Child Diet: Antioxidants Dietary Restriction Phytoestrogens Repair Deficiency: PMS2-Mismatch Mice

19 Framework for DGRT Research Dose Response Assessment --Rodent/human extrapolation Liver Toxicity Biomarkers Diet and Nutrition Genomics/Proteomics

20 Framework for DGRT Research Dose Response Assessment --Cancer/noncancer --Quantitative models Mechanistic Commonality Genomics/Proteomics

21 Framework for DGRT Research Chemical Specific Information --Genistein --Coumestrol --Leucomalachite Green --AZT --UV light/Phototoxicity

22 Cross Agency Collaboration DGRT DBT DBRA CDER CFSAN OWH NIEHS NTP EPA ACADEMIA DNT

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