1. Lecture 2 CHE 618

2. Agonists Partial Agonist Antagonist Inverse Agonist

3. +1 0 Functional Response Log[Drug] Full Agonist Partial Agonist Neutral Antagonist Full Inverse Agonist

4. Competitive Antagonism A1 + Receptor{A1 Receptor} effect A2 + Receptor {A2 Receptor}

5. R A1 A2 R A1 R A2 R A1 A2 Receptor-A1 is active Receptor-A1-A2 is active

6. Similar: In coordination chemistry Metal Ion + Ligand 1 + Ligand 2 In enzyme kinetics Enzyme + Substrate + Inhibitor

7. Dose-response curve What is there that is not poison? All things are poison and nothing without poison Solely the dose determines that a thing is not a poison