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Sequence/Structure Alignment Resources from NCBI Steve Bryant Protein Data Bank Rutgers University November 19, 2005.

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Presentation on theme: "Sequence/Structure Alignment Resources from NCBI Steve Bryant Protein Data Bank Rutgers University November 19, 2005."— Presentation transcript:

1 Sequence/Structure Alignment Resources from NCBI Steve Bryant Protein Data Bank Rutgers University November 19, 2005

2 … Structure look-up tools … Structure-structure alignments … Alignment tools in client software … Conserved domain family alignments * … Domain subfamily analysis tools * Sequence / Structure Alignment Resources from NCBI…

3 Entrez Search Engine...

4 Entrez Retrieval System... Protein Sequences MEDLINE Abstracts BLAST Sequence Similarity Protein Sequences 3D Structures Nucleotide Sequences Term Frequency Statistics VAST Structure Similarity BLAST Sequence Similarity 1,500,000 users... 60,000,000 hits... … per day

5 Entrez Search Engine...

6 Protein Sequence Records...

7 PubMed Links...

8

9 Related Structure Links...

10

11 Related Structure Link...

12 Related Structure Alignment...

13 Related Structure Alignment … Cn3D

14 Related Structure Links...

15 Related Structure Link...

16 Structure Neighbors of 2A14...

17 Structure Neighbor Alignment … Cn3D

18 Align Target to Template … Cn3D

19 Target-Template Alignment …

20 Leptin Threading Prediction, 1995 …

21 Threading Leptin 2005 … Cn3D

22 … Structure look-up tools … Structure-structure alignments … Alignment tools in client software … Conserved domain family alignments * … Domain subfamily analysis tools * Sequence / Structure Alignment Resources from NCBI…

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