1. Effects of per on longevity and fecundity in Drosophila James Lester Dr. Jadwiga Giebultowicz

2. Dr. Giebultowicz’s research Circadian Rhythms Clock Genes Tim Per Effects of expression

3. Increased longevity

4. Increased fecundity

5. Copulating Drosophila

6. My research Verify UAS Gal4 x UAS per results Eliminate cross breeding as variable Determine how per increases longevity and fecundity Cross-breeding – UAS Gal4 x UAS per (over expressed) – UAS per x White – UAS Gal4 x White – White x White – Wper01 x Wper01 (no expression)

7. Possible Longevity Factors Diet: How much food is eaten? How much is stored? Ovaries: Do the ovaries develop at different rates? Stress resistance: -Heat -Oxidative stress -Metabolic stress

8. Preliminary Metabolic Stress Results

9. Results Aging of cross-bred and over expressed is ongoing… Metabolic and oxidative tests are about to occur… Aging of virgins The fun has just begun!!!