1. Specific Immunity

2. What is specific immunity?
Third line of defense
Pathogen specific
Involves antigens and antibodies

3. What are B- and T-cells? Both start in marrow T cells B cells
Matures in _____
Kill infected/cancerous cells
Helper, cytotoxic
B cells
Matures in ______
Become plasma cells
Produce antibodies

4. What are antibodies and antigens?
Gamma () globulins
Also immunoglobins (Ig)
Antigens
Haptens
Epitopes
animation

5. The Two Types of Specific Immunity

6. What is antibody-mediated immunity?
AKA humoral immunity
Involves B cells
Manufacture of antibodies
Adhere to antigens
Marks pathogens for destruction

7. What types of antibodies are there?
IgA
IgG
IgM
IgE
IgD

8. How does antibody-mediated immunity work?
Clonal selection

9. Activation of B Cells T-independent antigen T-dependent antigen
Figure 17.6

10. How does antibody-mediated immunity work?
Clonal selection
Helper T cell must confirm (with exception—see later in lecture)
Plasma cell formation
Also memory cell formation
Antibody manufacture

11. How do antibodies work to protect me?
Bind with antigen
Possible outcomes
Opsonization
Agglutination
Complement activation
Neutralization

12. How does cell-mediated immunity work?
Types of T cells involved
Helper T (CD4)
Cytotoxic T (CD8)
Memory T
Delayed hypersensitivity T
Allergic reactions, organ rejection
Suppressor T
Antigen Presenting Cells (APC)
MHC-I
MHC-II

13. Antigen-Presenting Cells
Digest antigen
Ag fragments on APC surface with MHC
B cells
Dendritic Cells
Activated macrophages: Macrophages stimulated by ingesting Ag or by cytokines
Figure 17.12

14. How does cell-mediated immunity work?
Three Types of T cells involved
Cytotoxic lymphocyte
Activated macrophages
Natural killer cell

15. How does cell-mediated immunity work?
All players

16. How does I become immune to a pathogen?
Acquired immunity
Natural
Active
Passive
Artificial
passive

17. Do antibodies stay around forever?
Nearly so!
Primary vs. secondary immune response

18. What are monoclonal antibodies?
Use cancerous plasma cells
Myeloma
Hybridoma: cancerous + normal B cells together
animation

19. How are vaccines made? Killed whole cell Inactivated virus
Live/attenuated cell/virus
Antigenic molecule from cell/virus
Genetically engineered antigens

20. Figure 17.18