1. P.R. Smith, Histology - 2004. Interactive Questions POP-Quizzes Lab “Intros” (experimental) Download Lecture http://endeavor.med.nyu.edu Curriculum Histology CoursewareSyllabus

2. P.R. Smith, Histology - 2004. Skeletal Muscle

3. P.R. Smith, Histology - 2004. Vocabulary Sarcolemma Plasma Membrane SarcoplasmCytoplasm Sarcoplasmic ReticulumEndoplasmic Reticulum NexusGap Junction

4. P.R. Smith, Histology - 2004. Muscle Fasciculus Group of Muscle Fibers from Gray’s Anatomy

5. P.R. Smith, Histology - 2004. from Wheater

6. P.R. Smith, Histology - 2004. Kessel/Kardon

7. P.R. Smith, Histology - 2004. from Wheater

8. P.R. Smith, Histology - 2004.

10. Actin Myosin Myofibril Myofilaments from Gray’s Anatomy

11. P.R. Smith, Histology - 2004. immunoglobulin (Ig) fibronectin type III (fn III ) Titin http://www.chemsoc.org/exemplarchem/entries/kscott/titin.htm N C

12. P.R. Smith, Histology - 2004. M Z Z

15. Skeletal Muscle Control

16. P.R. Smith, Histology - 2004. from Gray’s Anatomy

17. P.R. Smith, Histology - 2004.

18. Junctional folds Nerve Terminal S

19. P.R. Smith, Histology - 2004.

21. T-tubule Terminal Cisterna Calsequestrin Ryanodine receptor Ryanodine receptor Dihydropyridine receptor

22. P.R. Smith, Histology - 2004. T-tubule Lumen Muscle sarcoplasm VV Ca 2+ T-T TC/SR Dihydropyridine receptor Ryanodine receptor Calsequestrin calcium ATPase

23. P.R. Smith, Histology - 2004. 1 2 3 4

25. Vale, Milligan and Johnson, 2000

26. P.R. Smith, Histology - 2004. Skeletal Muscle Development

27. P.R. Smith, Histology - 2004.

29. Cardiac Muscle

30. P.R. Smith, Histology - 2004.

32. Intercalated Disk

33. P.R. Smith, Histology - 2004. from Junqueira, Fig. 10-18 Intercalated Disk A B A CB A A Fascia adherens B Macula adherens (desmosome) C Gap junction

34. P.R. Smith, Histology - 2004. MA Cx-43

35. P.R. Smith, Histology - 2004. from Gray’s Anatomy

36. P.R. Smith, Histology - 2004. from Gray’s Anatomy Purkinje Fibers

37. P.R. Smith, Histology - 2004. from WheaterCx-45

38. P.R. Smith, Histology - 2004. Smooth Muscle

39. P.R. Smith, Histology - 2004.

41. E.Robbins

44. DB CA Col GJ M E. Robbins

45. P.R. Smith, Histology - 2004.

47. Cytoplasmic Matrix

48. P.R. Smith, Histology - 2004. Actin Filament Attachment

49. P.R. Smith, Histology - 2004. Smooth Muscle Contraction S.J. Gunst, et al., 2003

50. P.R. Smith, Histology - 2004. Getting ready for Lab.

51. P.R. Smith, Histology - 2004. Skeletal Smooth

53. Homework: for 17 th Feb. Things to review … Actin-Myosin ATPase cycle Control of the Actin-Myosin interaction (both striated and smooth muscle) Intra-cellular signaling: the role of Calcium Myosin isoforms, fast and slow muscle fibers [Sci.Am., Sep. 2000, 49-55] Check out the on-line POP-Quizzes